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HIV-infected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortality.
Serrano-Villar S, Sainz T, Lee SA, Hunt PW, Sinclair E, Shacklett BL, Ferre AL, Hayes TL, Somsouk M, Hsue PY, Van Natta ML, Meinert CL, Lederman MM, Hatano H, Jain V, Huang Y, Hecht FM, Martin JN, McCune JM, Moreno S, Deeks SG. Serrano-Villar S, et al. Among authors: hecht fm. PLoS Pathog. 2014 May 15;10(5):e1004078. doi: 10.1371/journal.ppat.1004078. eCollection 2014 May. PLoS Pathog. 2014. PMID: 24831517 Free PMC article. Clinical Trial.
Provider assessment of adherence to HIV antiretroviral therapy.
Bangsberg DR, Hecht FM, Clague H, Charlebois ED, Ciccarone D, Chesney M, Moss A. Bangsberg DR, et al. Among authors: hecht fm. J Acquir Immune Defic Syndr. 2001 Apr 15;26(5):435-42. doi: 10.1097/00126334-200104150-00005. J Acquir Immune Defic Syndr. 2001. PMID: 11391162
Increased HLA-DR expression on peripheral blood monocytes in subsets of subjects with primary HIV infection is associated with elevated CD4 T-cell apoptosis and CD4 T-cell depletion.
Gascon RL, Narváez AB, Zhang R, Kahn JO, Hecht FM, Herndier BG, McGrath MS. Gascon RL, et al. Among authors: hecht fm. J Acquir Immune Defic Syndr. 2002 Jun 1;30(2):146-53. doi: 10.1097/00042560-200206010-00002. J Acquir Immune Defic Syndr. 2002. PMID: 12045676 Clinical Trial.
613 results