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Deficiency of PTP1B in POMC neurons leads to alterations in energy balance and homeostatic response to cold exposure.
De Jonghe BC, Hayes MR, Banno R, Skibicka KP, Zimmer DJ, Bowen KA, Leichner TM, Alhadeff AL, Kanoski SE, Cyr NE, Nillni EA, Grill HJ, Bence KK. De Jonghe BC, et al. Among authors: bence kk. Am J Physiol Endocrinol Metab. 2011 Jun;300(6):E1002-11. doi: 10.1152/ajpendo.00639.2010. Epub 2011 Mar 15. Am J Physiol Endocrinol Metab. 2011. PMID: 21406615 Free PMC article.
Leptin and insulin act on POMC neurons to promote the browning of white fat.
Dodd GT, Decherf S, Loh K, Simonds SE, Wiede F, Balland E, Merry TL, Münzberg H, Zhang ZY, Kahn BB, Neel BG, Bence KK, Andrews ZB, Cowley MA, Tiganis T. Dodd GT, et al. Among authors: bence kk. Cell. 2015 Jan 15;160(1-2):88-104. doi: 10.1016/j.cell.2014.12.022. Cell. 2015. PMID: 25594176 Free PMC article.
Neuronal protein tyrosine phosphatase 1B deficiency results in inhibition of hypothalamic AMPK and isoform-specific activation of AMPK in peripheral tissues.
Xue B, Pulinilkunnil T, Murano I, Bence KK, He H, Minokoshi Y, Asakura K, Lee A, Haj F, Furukawa N, Catalano KJ, Delibegovic M, Balschi JA, Cinti S, Neel BG, Kahn BB. Xue B, et al. Among authors: bence kk. Mol Cell Biol. 2009 Aug;29(16):4563-73. doi: 10.1128/MCB.01914-08. Epub 2009 Jun 15. Mol Cell Biol. 2009. PMID: 19528236 Free PMC article.
56 results