Kehler J - Search Results

1

Novel aza-analogous ergoline derived scaffolds as potent serotonin 5-HT₆ and dopamine D₂ receptor ligands.

Krogsgaard-Larsen N, Jensen AA, Schrøder TJ, Christoffersen CT, Kehler J. Krogsgaard-Larsen N, et al. Among authors: kehler j. J Med Chem. 2014 Jul 10;57(13):5823-8. doi: 10.1021/jm5003759. Epub 2014 Jun 18. J Med Chem. 2014. PMID: 24878269

2

Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles as dual serotonin 5-HT2C and 5-HT6 receptor ligands.

Krogsgaard-Larsen N, Jensen AA, Kehler J. Krogsgaard-Larsen N, et al. Among authors: kehler j. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5431-3. doi: 10.1016/j.bmcl.2010.07.105. Epub 2010 Aug 3. Bioorg Med Chem Lett. 2010. PMID: 20719507

3

Revision of the classical dopamine D2 agonist pharmacophore based on an integrated medicinal chemistry, homology modelling and computational docking approach.

Krogsgaard-Larsen N, Harpsøe K, Kehler J, Christoffersen CT, Brøsen P, Balle T. Krogsgaard-Larsen N, et al. Among authors: kehler j. Neurochem Res. 2014 Oct;39(10):1997-2007. doi: 10.1007/s11064-014-1314-2. Epub 2014 Jul 24. Neurochem Res. 2014. PMID: 25056287 Review.

4

Discovery of benzamide analogues as a novel class of 5-HT₃ receptor agonists.

Jørgensen CG, Frølund B, Kehler J, Jensen AA. Jørgensen CG, et al. Among authors: kehler j. ChemMedChem. 2011 Apr 4;6(4):725-36. doi: 10.1002/cmdc.201000444. Epub 2011 Jan 18. ChemMedChem. 2011. PMID: 21246737

5

Discovery of the first selective inhibitor of excitatory amino acid transporter subtype 1.

Jensen AA, Erichsen MN, Nielsen CW, Stensbøl TB, Kehler J, Bunch L. Jensen AA, et al. Among authors: kehler j. J Med Chem. 2009 Feb 26;52(4):912-5. doi: 10.1021/jm8013458. J Med Chem. 2009. PMID: 19161278

6

Synthesis and biological evaluation of 4-(aminomethyl)-1-hydroxypyrazole analogues of muscimol as γ-aminobutyric acid(a) receptor agonists.

Petersen JG, Bergmann R, Møller HA, Jørgensen CG, Nielsen B, Kehler J, Frydenvang K, Kristensen J, Balle T, Jensen AA, Kristiansen U, Frølund B. Petersen JG, et al. Among authors: kehler j. J Med Chem. 2013 Feb 14;56(3):993-1006. doi: 10.1021/jm301473k. Epub 2013 Jan 23. J Med Chem. 2013. PMID: 23294161

7

N-Methylanilide and N-methylbenzamide derivatives as phosphodiesterase 10A (PDE10A) inhibitors.

Kilburn JP, Kehler J, Langgård M, Erichsen MN, Leth-Petersen S, Larsen M, Christoffersen CT, Nielsen J. Kilburn JP, et al. Among authors: kehler j. Bioorg Med Chem. 2013 Oct 1;21(19):6053-62. doi: 10.1016/j.bmc.2013.07.030. Epub 2013 Jul 23. Bioorg Med Chem. 2013. PMID: 23978358

8

Synthesis and SAR study of novel tricyclic pyrazoles as potent phosphodiesterase 10A inhibitors.

Dore A, Asproni B, Scampuddu A, Pinna GA, Christoffersen CT, Langgård M, Kehler J. Dore A, et al. Among authors: kehler j. Eur J Med Chem. 2014 Sep 12;84:181-93. doi: 10.1016/j.ejmech.2014.07.020. Epub 2014 Jul 7. Eur J Med Chem. 2014. PMID: 25016376

9

Discovery of 2-(Imidazo[1,2- b]pyridazin-2-yl)acetic Acid as a New Class of Ligands Selective for the γ-Hydroxybutyric Acid (GHB) High-Affinity Binding Sites.

Krall J, Bavo F, Falk-Petersen CB, Jensen CH, Nielsen JO, Tian Y, Anglani V, Kongstad KT, Piilgaard L, Nielsen B, Gloriam DE, Kehler J, Jensen AA, Harpsøe K, Wellendorph P, Frølund B. Krall J, et al. Among authors: kehler j. J Med Chem. 2019 Mar 14;62(5):2798-2813. doi: 10.1021/acs.jmedchem.9b00131. Epub 2019 Feb 27. J Med Chem. 2019. PMID: 30763084

10

Triazoloquinazolines as a novel class of phosphodiesterase 10A (PDE10A) inhibitors.

Kehler J, Ritzen A, Langgård M, Petersen SL, Farah MM, Bundgaard C, Christoffersen CT, Nielsen J, Kilburn JP. Kehler J, et al. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3738-42. doi: 10.1016/j.bmcl.2011.04.067. Epub 2011 Apr 30. Bioorg Med Chem Lett. 2011. PMID: 21602043

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