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Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ.
Perino A, Ghigo A, Ferrero E, Morello F, Santulli G, Baillie GS, Damilano F, Dunlop AJ, Pawson C, Walser R, Levi R, Altruda F, Silengo L, Langeberg LK, Neubauer G, Heymans S, Lembo G, Wymann MP, Wetzker R, Houslay MD, Iaccarino G, Scott JD, Hirsch E. Perino A, et al. Among authors: hirsch e. Mol Cell. 2011 Apr 8;42(1):84-95. doi: 10.1016/j.molcel.2011.01.030. Mol Cell. 2011. PMID: 21474070 Free PMC article.
PI3Kγ integrates cAMP and Akt signalling of the μ-opioid receptor.
Madishetti S, Schneble N, König C, Hirsch E, Schulz S, Müller JP, Wetzker R. Madishetti S, et al. Among authors: hirsch e. Br J Pharmacol. 2014 Jul;171(13):3328-37. doi: 10.1111/bph.12698. Br J Pharmacol. 2014. PMID: 24654606 Free PMC article.
Combined inhibition of PI3Kβ and PI3Kγ reduces fat mass by enhancing α-MSH-dependent sympathetic drive.
Perino A, Beretta M, Kilić A, Ghigo A, Carnevale D, Repetto IE, Braccini L, Longo D, Liebig-Gonglach M, Zaglia T, Iacobucci R, Mongillo M, Wetzker R, Bauer M, Aime S, Vercelli A, Lembo G, Pfeifer A, Hirsch E. Perino A, et al. Among authors: hirsch e. Sci Signal. 2014 Nov 18;7(352):ra110. doi: 10.1126/scisignal.2005485. Sci Signal. 2014. PMID: 25406378
1,546 results