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A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents.
Finan B, Yang B, Ottaway N, Smiley DL, Ma T, Clemmensen C, Chabenne J, Zhang L, Habegger KM, Fischer K, Campbell JE, Sandoval D, Seeley RJ, Bleicher K, Uhles S, Riboulet W, Funk J, Hertel C, Belli S, Sebokova E, Conde-Knape K, Konkar A, Drucker DJ, Gelfanov V, Pfluger PT, Müller TD, Perez-Tilve D, DiMarchi RD, Tschöp MH. Finan B, et al. Among authors: seeley rj. Nat Med. 2015 Jan;21(1):27-36. doi: 10.1038/nm.3761. Epub 2014 Dec 8. Nat Med. 2015. PMID: 25485909
The Role of Pancreatic Preproglucagon in Glucose Homeostasis in Mice.
Chambers AP, Sorrell JE, Haller A, Roelofs K, Hutch CR, Kim KS, Gutierrez-Aguilar R, Li B, Drucker DJ, D'Alessio DA, Seeley RJ, Sandoval DA. Chambers AP, et al. Among authors: seeley rj. Cell Metab. 2017 Apr 4;25(4):927-934.e3. doi: 10.1016/j.cmet.2017.02.008. Epub 2017 Mar 16. Cell Metab. 2017. PMID: 28325479 Free PMC article.
The glucagon-like peptide-1 receptor in the ventromedial hypothalamus reduces short-term food intake in male mice by regulating nutrient sensor activity.
Burmeister MA, Brown JD, Ayala JE, Stoffers DA, Sandoval DA, Seeley RJ, Ayala JE. Burmeister MA, et al. Among authors: seeley rj. Am J Physiol Endocrinol Metab. 2017 Dec 1;313(6):E651-E662. doi: 10.1152/ajpendo.00113.2017. Epub 2017 Aug 15. Am J Physiol Endocrinol Metab. 2017. PMID: 28811293 Free PMC article.
413 results