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Incomplete deletion of IL-4Rα by LysM(Cre) reveals distinct subsets of M2 macrophages controlling inflammation and fibrosis in chronic schistosomiasis.
Vannella KM, Barron L, Borthwick LA, Kindrachuk KN, Narasimhan PB, Hart KM, Thompson RW, White S, Cheever AW, Ramalingam TR, Wynn TA. Vannella KM, et al. Among authors: borthwick la. PLoS Pathog. 2014 Sep 11;10(9):e1004372. doi: 10.1371/journal.ppat.1004372. eCollection 2014 Sep. PLoS Pathog. 2014. PMID: 25211233 Free PMC article.
Cytokine mediated tissue fibrosis.
Borthwick LA, Wynn TA, Fisher AJ. Borthwick LA, et al. Biochim Biophys Acta. 2013 Jul;1832(7):1049-60. doi: 10.1016/j.bbadis.2012.09.014. Epub 2012 Oct 6. Biochim Biophys Acta. 2013. PMID: 23046809 Free PMC article. Review.
Role of arginase 1 from myeloid cells in th2-dominated lung inflammation.
Barron L, Smith AM, El Kasmi KC, Qualls JE, Huang X, Cheever A, Borthwick LA, Wilson MS, Murray PJ, Wynn TA. Barron L, et al. Among authors: borthwick la. PLoS One. 2013 Apr 24;8(4):e61961. doi: 10.1371/journal.pone.0061961. Print 2013. PLoS One. 2013. PMID: 23637937 Free PMC article.
TNF-α/IL-17 synergy inhibits IL-13 bioactivity via IL-13Rα2 induction.
Badalyan V, Thompson R, Addo K, Borthwick LA, Fisher AJ, Ort T, Myers TG, Wynn TA, Ramalingam TR. Badalyan V, et al. Among authors: borthwick la. J Allergy Clin Immunol. 2014 Oct;134(4):975-8.e5. doi: 10.1016/j.jaci.2014.05.019. Epub 2014 Jun 20. J Allergy Clin Immunol. 2014. PMID: 24954262 Free PMC article.
TH2 and TH17 inflammatory pathways are reciprocally regulated in asthma.
Choy DF, Hart KM, Borthwick LA, Shikotra A, Nagarkar DR, Siddiqui S, Jia G, Ohri CM, Doran E, Vannella KM, Butler CA, Hargadon B, Sciurba JC, Gieseck RL, Thompson RW, White S, Abbas AR, Jackman J, Wu LC, Egen JG, Heaney LG, Ramalingam TR, Arron JR, Wynn TA, Bradding P. Choy DF, et al. Among authors: borthwick la. Sci Transl Med. 2015 Aug 19;7(301):301ra129. doi: 10.1126/scitranslmed.aab3142. Sci Transl Med. 2015. PMID: 26290411
Acidic chitinase primes the protective immune response to gastrointestinal nematodes.
Vannella KM, Ramalingam TR, Hart KM, de Queiroz Prado R, Sciurba J, Barron L, Borthwick LA, Smith AD, Mentink-Kane M, White S, Thompson RW, Cheever AW, Bock K, Moore I, Fitz LJ, Urban JF Jr, Wynn TA. Vannella KM, et al. Among authors: borthwick la. Nat Immunol. 2016 May;17(5):538-44. doi: 10.1038/ni.3417. Epub 2016 Apr 4. Nat Immunol. 2016. PMID: 27043413 Free PMC article.
69 results