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An exploratory double-blind, randomized clinical trial with selisistat, a SirT1 inhibitor, in patients with Huntington's disease.
Süssmuth SD, Haider S, Landwehrmeyer GB, Farmer R, Frost C, Tripepi G, Andersen CA, Di Bacco M, Lamanna C, Diodato E, Massai L, Diamanti D, Mori E, Magnoni L, Dreyhaupt J, Schiefele K, Craufurd D, Saft C, Rudzinska M, Ryglewicz D, Orth M, Brzozy S, Baran A, Pollio G, Andre R, Tabrizi SJ, Darpo B, Westerberg G; PADDINGTON Consortium. Süssmuth SD, et al. Among authors: westerberg g. Br J Clin Pharmacol. 2015 Mar;79(3):465-76. doi: 10.1111/bcp.12512. Br J Clin Pharmacol. 2015. PMID: 25223731 Free PMC article. Clinical Trial.
A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease.
Smith MR, Syed A, Lukacsovich T, Purcell J, Barbaro BA, Worthge SA, Wei SR, Pollio G, Magnoni L, Scali C, Massai L, Franceschini D, Camarri M, Gianfriddo M, Diodato E, Thomas R, Gokce O, Tabrizi SJ, Caricasole A, Landwehrmeyer B, Menalled L, Murphy C, Ramboz S, Luthi-Carter R, Westerberg G, Marsh JL. Smith MR, et al. Among authors: westerberg g. Hum Mol Genet. 2014 Jun 1;23(11):2995-3007. doi: 10.1093/hmg/ddu010. Epub 2014 Jan 16. Hum Mol Genet. 2014. PMID: 24436303 Free PMC article.
MAO-A inhibition in brain after dosing with esuprone, moclobemide and placebo in healthy volunteers: in vivo studies with positron emission tomography.
Bergström M, Westerberg G, Németh G, Traut M, Gross G, Greger G, Müller-Peltzer H, Safer A, Eckernäs SA, Grahnér A, Långström B. Bergström M, et al. Among authors: westerberg g. Eur J Clin Pharmacol. 1997;52(2):121-8. doi: 10.1007/s002280050260. Eur J Clin Pharmacol. 1997. PMID: 9174681 Clinical Trial.
[11C]Hyaluronan uptake with positron emission tomography in liver disease.
Lindqvist U, Westerberg G, Bergström M, Torsteindottir I, Gustafson S, Sundin A, Lööf L, Långström B. Lindqvist U, et al. Among authors: westerberg g. Eur J Clin Invest. 2000 Jul;30(7):600-7. doi: 10.1046/j.1365-2362.2000.00675.x. Eur J Clin Invest. 2000. PMID: 10886300 Clinical Trial.
34 results