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Ponatinib inhibits polyclonal drug-resistant KIT oncoproteins and shows therapeutic potential in heavily pretreated gastrointestinal stromal tumor (GIST) patients.
Garner AP, Gozgit JM, Anjum R, Vodala S, Schrock A, Zhou T, Serrano C, Eilers G, Zhu M, Ketzer J, Wardwell S, Ning Y, Song Y, Kohlmann A, Wang F, Clackson T, Heinrich MC, Fletcher JA, Bauer S, Rivera VM. Garner AP, et al. Among authors: clackson t. Clin Cancer Res. 2014 Nov 15;20(22):5745-5755. doi: 10.1158/1078-0432.CCR-14-1397. Epub 2014 Sep 19. Clin Cancer Res. 2014. PMID: 25239608 Free PMC article.
A humanized system for pharmacologic control of gene expression.
Rivera VM, Clackson T, Natesan S, Pollock R, Amara JF, Keenan T, Magari SR, Phillips T, Courage NL, Cerasoli F Jr, Holt DA, Gilman M. Rivera VM, et al. Among authors: clackson t. Nat Med. 1996 Sep;2(9):1028-32. doi: 10.1038/nm0996-1028. Nat Med. 1996. PMID: 8782462
A versatile synthetic dimerizer for the regulation of protein-protein interactions.
Amara JF, Clackson T, Rivera VM, Guo T, Keenan T, Natesan S, Pollock R, Yang W, Courage NL, Holt DA, Gilman M. Amara JF, et al. Among authors: clackson t. Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10618-23. doi: 10.1073/pnas.94.20.10618. Proc Natl Acad Sci U S A. 1997. PMID: 9380684 Free PMC article.
A ligand-reversible dimerization system for controlling protein-protein interactions.
Rollins CT, Rivera VM, Woolfson DN, Keenan T, Hatada M, Adams SE, Andrade LJ, Yaeger D, van Schravendijk MR, Holt DA, Gilman M, Clackson T. Rollins CT, et al. Among authors: clackson t. Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7096-101. doi: 10.1073/pnas.100101997. Proc Natl Acad Sci U S A. 2000. PMID: 10852943 Free PMC article.
Inhibition of wild-type and mutant Bcr-Abl by AP23464, a potent ATP-based oncogenic protein kinase inhibitor: implications for CML.
O'Hare T, Pollock R, Stoffregen EP, Keats JA, Abdullah OM, Moseson EM, Rivera VM, Tang H, Metcalf CA 3rd, Bohacek RS, Wang Y, Sundaramoorthi R, Shakespeare WC, Dalgarno D, Clackson T, Sawyer TK, Deininger MW, Druker BJ. O'Hare T, et al. Among authors: clackson t. Blood. 2004 Oct 15;104(8):2532-9. doi: 10.1182/blood-2004-05-1851. Epub 2004 Jul 15. Blood. 2004. PMID: 15256422 Free article.
89 results