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Identification and evaluation of improved 4'-O-(alkyl) 4,5-disubstituted 2-deoxystreptamines as next-generation aminoglycoside antibiotics.
Duscha S, Boukari H, Shcherbakov D, Salian S, Silva S, Kendall A, Kato T, Akbergenov R, Perez-Fernandez D, Bernet B, Vaddi S, Thommes P, Schacht J, Crich D, Vasella A, Böttger EC. Duscha S, et al. Among authors: crich d. mBio. 2014 Sep 30;5(5):e01827-14. doi: 10.1128/mBio.01827-14. mBio. 2014. PMID: 25271289 Free PMC article.
Fluorine-decoupled carbon spectroscopy for the determination of configuration at fully substituted, trifluoromethyl- and perfluoroalkyl-bearing carbons: comparison with 19F-1H heteronuclear Overhauser effect spectroscopy.
Mandhapati AR, Kato T, Matsushita T, Ksebati B, Vasella A, Böttger EC, Crich D. Mandhapati AR, et al. Among authors: crich d. J Org Chem. 2015 Feb 6;80(3):1754-63. doi: 10.1021/jo502677a. Epub 2015 Jan 20. J Org Chem. 2015. PMID: 25561269 Free PMC article.
Synthesis and Antiribosomal Activities of 4'-O-, 6'-O-, 4″-O-, 4',6'-O- and 4″,6″-O-Derivatives in the Kanamycin Series Indicate Differing Target Selectivity Patterns between the 4,5- and 4,6-Series of Disubstituted 2-Deoxystreptamine Aminoglycoside Antibiotics.
Kato T, Yang G, Teo Y, Juskeviciene R, Perez-Fernandez D, Shinde HM, Salian S, Bernet B, Vasella A, Böttger EC, Crich D. Kato T, et al. Among authors: crich d. ACS Infect Dis. 2015 Oct 9;1(10):479-86. doi: 10.1021/acsinfecdis.5b00069. Epub 2015 Aug 6. ACS Infect Dis. 2015. PMID: 27623314
Stereospecific synthesis of methyl 2-amino-2-deoxy-(6S)-deuterio-α,β-d-glucopyranoside and methyl 2,6-diamino-2,6-dideoxy-(6R)-deuterio-α,β-d-glucopyranoside: Side chain conformations of the 2-amino-2-deoxy and 2,6-diamino-2,6-dideoxyglucopyranosides.
Kato T, Vasella A, Crich D. Kato T, et al. Among authors: crich d. Carbohydr Res. 2017 Aug 7;448:10-17. doi: 10.1016/j.carres.2017.05.015. Epub 2017 May 19. Carbohydr Res. 2017. PMID: 28554123 Free PMC article.
Structure-Based Design and Synthesis of Apramycin-Paromomycin Analogues: Importance of the Configuration at the 6'-Position and Differences between the 6'-Amino and Hydroxy Series.
Mandhapati AR, Yang G, Kato T, Shcherbakov D, Hobbie SN, Vasella A, Böttger EC, Crich D. Mandhapati AR, et al. Among authors: crich d. J Am Chem Soc. 2017 Oct 18;139(41):14611-14619. doi: 10.1021/jacs.7b07754. Epub 2017 Oct 9. J Am Chem Soc. 2017. PMID: 28892368 Free PMC article.
Synthesis of Conformationally-Locked cis- and trans-Bicyclo[4.4.0] Mono-, Di-, and Trioxadecane Modifications of Galacto- and Glucopyranose; Experimental Limiting 3JH,H Coupling Constants for the Estimation of Carbohydrate Side Chain Populations and Beyond.
Amarasekara H, Dharuman S, Kato T, Crich D. Amarasekara H, et al. Among authors: crich d. J Org Chem. 2018 Jan 19;83(2):881-897. doi: 10.1021/acs.joc.7b02891. Epub 2018 Jan 3. J Org Chem. 2018. PMID: 29241001 Free PMC article.
273 results