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Identification and evaluation of improved 4'-O-(alkyl) 4,5-disubstituted 2-deoxystreptamines as next-generation aminoglycoside antibiotics.
Duscha S, Boukari H, Shcherbakov D, Salian S, Silva S, Kendall A, Kato T, Akbergenov R, Perez-Fernandez D, Bernet B, Vaddi S, Thommes P, Schacht J, Crich D, Vasella A, Böttger EC. Duscha S, et al. Among authors: perez fernandez d. mBio. 2014 Sep 30;5(5):e01827-14. doi: 10.1128/mBio.01827-14. mBio. 2014. PMID: 25271289 Free PMC article.
Dissociation of antibacterial activity and aminoglycoside ototoxicity in the 4-monosubstituted 2-deoxystreptamine apramycin.
Matt T, Ng CL, Lang K, Sha SH, Akbergenov R, Shcherbakov D, Meyer M, Duscha S, Xie J, Dubbaka SR, Perez-Fernandez D, Vasella A, Ramakrishnan V, Schacht J, Böttger EC. Matt T, et al. Among authors: perez fernandez d. Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):10984-9. doi: 10.1073/pnas.1204073109. Epub 2012 Jun 14. Proc Natl Acad Sci U S A. 2012. PMID: 22699498 Free PMC article.
4'-O-substitutions determine selectivity of aminoglycoside antibiotics.
Perez-Fernandez D, Shcherbakov D, Matt T, Leong NC, Kudyba I, Duscha S, Boukari H, Patak R, Dubbaka SR, Lang K, Meyer M, Akbergenov R, Freihofer P, Vaddi S, Thommes P, Ramakrishnan V, Vasella A, Böttger EC. Perez-Fernandez D, et al. Nat Commun. 2014;5:3112. doi: 10.1038/ncomms4112. Nat Commun. 2014. PMID: 24473108 Free PMC article.
Synthesis and Antiribosomal Activities of 4'-O-, 6'-O-, 4″-O-, 4',6'-O- and 4″,6″-O-Derivatives in the Kanamycin Series Indicate Differing Target Selectivity Patterns between the 4,5- and 4,6-Series of Disubstituted 2-Deoxystreptamine Aminoglycoside Antibiotics.
Kato T, Yang G, Teo Y, Juskeviciene R, Perez-Fernandez D, Shinde HM, Salian S, Bernet B, Vasella A, Böttger EC, Crich D. Kato T, et al. Among authors: perez fernandez d. ACS Infect Dis. 2015 Oct 9;1(10):479-86. doi: 10.1021/acsinfecdis.5b00069. Epub 2015 Aug 6. ACS Infect Dis. 2015. PMID: 27623314
Predicting the evolution of COVID-19 mortality risk: A Recurrent Neural Network approach.
Villegas M, Gonzalez-Agirre A, Gutiérrez-Fandiño A, Armengol-Estapé J, Carrino CP, Pérez-Fernández D, Soares F, Serrano P, Pedrera M, García N, Valencia A. Villegas M, et al. Among authors: perez fernandez d. Comput Methods Programs Biomed Update. 2023;3:100089. doi: 10.1016/j.cmpbup.2022.100089. Epub 2022 Dec 29. Comput Methods Programs Biomed Update. 2023. PMID: 36593771 Free PMC article.
Dinuclear RuII(bipy)2 Derivatives: Structural, Biological, and in Vivo Zebrafish Toxicity Evaluation.
Lenis-Rojas OA, Roma-Rodrigues C, Fernandes AR, Marques F, Pérez-Fernández D, Guerra-Varela J, Sánchez L, Vázquez-García D, López-Torres M, Fernández A, Fernández JJ. Lenis-Rojas OA, et al. Among authors: perez fernandez d. Inorg Chem. 2017 Jun 19;56(12):7127-7144. doi: 10.1021/acs.inorgchem.7b00790. Epub 2017 Jun 6. Inorg Chem. 2017. PMID: 28585811
Heteroleptic mononuclear compounds of ruthenium(ii): synthesis, structural analyses, in vitro antitumor activity and in vivo toxicity on zebrafish embryos.
Lenis-Rojas OA, Fernandes AR, Roma-Rodrigues C, Baptista PV, Marques F, Pérez-Fernández D, Guerra-Varela J, Sánchez L, Vázquez-García D, Torres ML, Fernández A, Fernández JJ. Lenis-Rojas OA, et al. Among authors: perez fernandez d. Dalton Trans. 2016 Dec 21;45(47):19127-19140. doi: 10.1039/c6dt03591d. Epub 2016 Nov 21. Dalton Trans. 2016. PMID: 27868117
12 results