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New structure-activity relationship studies in a series of N,N-bis(cyclohexanol)amine aryl esters as potent reversers of P-glycoprotein-mediated multidrug resistance (MDR).
Orlandi F, Coronnello M, Bellucci C, Dei S, Guandalini L, Manetti D, Martelli C, Romanelli MN, Scapecchi S, Salerno M, Menif H, Bello I, Mini E, Teodori E. Orlandi F, et al. Among authors: coronnello m. Bioorg Med Chem. 2013 Jan 15;21(2):456-65. doi: 10.1016/j.bmc.2012.11.019. Epub 2012 Nov 24. Bioorg Med Chem. 2013. PMID: 23245571
Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug resistance (MDR) modulators.
Dei S, Braconi L, Trezza A, Menicatti M, Contino M, Coronnello M, Chiaramonte N, Manetti D, Perrone MG, Romanelli MN, Udomtanakunchai C, Colabufo NA, Bartolucci G, Spiga O, Salerno M, Teodori E. Dei S, et al. Among authors: coronnello m. Eur J Med Chem. 2019 Jun 15;172:71-94. doi: 10.1016/j.ejmech.2019.03.054. Epub 2019 Mar 27. Eur J Med Chem. 2019. PMID: 30947123
New Dual P-Glycoprotein (P-gp) and Human Carbonic Anhydrase XII (hCA XII) Inhibitors as Multidrug Resistance (MDR) Reversers in Cancer Cells.
Braconi L, Teodori E, Riganti C, Coronnello M, Nocentini A, Bartolucci G, Pallecchi M, Contino M, Manetti D, Romanelli MN, Supuran CT, Dei S. Braconi L, et al. Among authors: coronnello m. J Med Chem. 2022 Nov 10;65(21):14655-14672. doi: 10.1021/acs.jmedchem.2c01175. Epub 2022 Oct 21. J Med Chem. 2022. PMID: 36269278 Free PMC article.
45 results