Sharma S - Search Results

1

Reversible inhibition of lysine specific demethylase 1 is a novel anti-tumor strategy for poorly differentiated endometrial carcinoma.

Theisen ER, Gajiwala S, Bearss J, Sorna V, Sharma S, Janat-Amsbury M. Theisen ER, et al. Among authors: sharma s. BMC Cancer. 2014 Oct 9;14:752. doi: 10.1186/1471-2407-14-752. BMC Cancer. 2014. PMID: 25300887 Free PMC article.

2

Of mice and men: opportunities to use genetically engineered mouse models of synovial sarcoma for preclinical cancer therapeutic evaluation.

Jones KB, Haldar M, Schiffman JD, Cannon-Albright L, Lessnick SL, Sharma S, Capecchi MR, Randall RL. Jones KB, et al. Among authors: sharma s. Cancer Control. 2011 Jul;18(3):196-203. doi: 10.1177/107327481101800307. Cancer Control. 2011. PMID: 21666582 Free PMC article. Review.

3

Design, Synthesis and Biological Evaluation of a Series of Novel Axl Kinase Inhibitors.

Mollard A, Warner SL, Call LT, Wade ML, Bearss JJ, Verma A, Sharma S, Vankayalapati H, Bearss DJ. Mollard A, et al. Among authors: sharma s. ACS Med Chem Lett. 2011 Dec 8;2(12):907-912. doi: 10.1021/ml200198x. ACS Med Chem Lett. 2011. PMID: 22247788 Free PMC article.

4

Mechanism and relevance of EWS/FLI-mediated transcriptional repression in Ewing sarcoma.

Sankar S, Bell R, Stephens B, Zhuo R, Sharma S, Bearss DJ, Lessnick SL. Sankar S, et al. Among authors: sharma s. Oncogene. 2013 Oct 17;32(42):5089-100. doi: 10.1038/onc.2012.525. Epub 2012 Nov 26. Oncogene. 2013. PMID: 23178492 Free PMC article.

5

High-throughput virtual screening identifies novel N'-(1-phenylethylidene)-benzohydrazides as potent, specific, and reversible LSD1 inhibitors.

Sorna V, Theisen ER, Stephens B, Warner SL, Bearss DJ, Vankayalapati H, Sharma S. Sorna V, et al. Among authors: sharma s. J Med Chem. 2013 Dec 12;56(23):9496-508. doi: 10.1021/jm400870h. Epub 2013 Nov 23. J Med Chem. 2013. PMID: 24237195

6

Reversible LSD1 inhibition interferes with global EWS/ETS transcriptional activity and impedes Ewing sarcoma tumor growth.

Sankar S, Theisen ER, Bearss J, Mulvihill T, Hoffman LM, Sorna V, Beckerle MC, Sharma S, Lessnick SL. Sankar S, et al. Among authors: sharma s. Clin Cancer Res. 2014 Sep 1;20(17):4584-97. doi: 10.1158/1078-0432.CCR-14-0072. Epub 2014 Jun 24. Clin Cancer Res. 2014. PMID: 24963049 Free PMC article.

7

Design, Synthesis, and Biological Evaluation of a Series of Anthracene-9,10-dione Dioxime β-Catenin Pathway Inhibitors.

Soldi R, Horrigan SK, Cholody MW, Padia J, Sorna V, Bearss J, Gilcrease G, Bhalla K, Verma A, Vankayalapati H, Sharma S. Soldi R, et al. Among authors: sharma s. J Med Chem. 2015 Aug 13;58(15):5854-62. doi: 10.1021/acs.jmedchem.5b00460. Epub 2015 Jul 31. J Med Chem. 2015. PMID: 26182238

8

Reversible lysine-specific demethylase 1 antagonist HCI-2509 inhibits growth and decreases c-MYC in castration- and docetaxel-resistant prostate cancer cells.

Gupta S, Weston A, Bearrs J, Thode T, Neiss A, Soldi R, Sharma S. Gupta S, et al. Among authors: sharma s. Prostate Cancer Prostatic Dis. 2016 Dec;19(4):349-357. doi: 10.1038/pcan.2016.21. Epub 2016 Jun 28. Prostate Cancer Prostatic Dis. 2016. PMID: 27349498 Free PMC article.

9

A phase I study to determine the pharmacokinetics and urinary excretion of belinostat and metabolites in patients with advanced solid tumors.

Bailey H, McPherson JP, Bailey EB, Werner TL, Gupta S, Batten J, Reddy G, Bhat G, Sharma S, Agarwal N. Bailey H, et al. Among authors: sharma s. Cancer Chemother Pharmacol. 2016 Nov;78(5):1059-1071. doi: 10.1007/s00280-016-3167-7. Epub 2016 Oct 15. Cancer Chemother Pharmacol. 2016. PMID: 27744565 Clinical Trial.

10

A phase I open-label dose-escalation study of the anti-HER3 monoclonal antibody LJM716 in patients with advanced squamous cell carcinoma of the esophagus or head and neck and HER2-overexpressing breast or gastric cancer.

Reynolds KL, Bedard PL, Lee SH, Lin CC, Tabernero J, Alsina M, Cohen E, Baselga J, Blumenschein G Jr, Graham DM, Garrido-Laguna I, Juric D, Sharma S, Salgia R, Seroutou A, Tian X, Fernandez R, Morozov A, Sheng Q, Ramkumar T, Zubel A, Bang YJ. Reynolds KL, et al. Among authors: sharma s. BMC Cancer. 2017 Sep 12;17(1):646. doi: 10.1186/s12885-017-3641-6. BMC Cancer. 2017. PMID: 28899363 Free PMC article. Clinical Trial.

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