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Oxygen-dependent hydroxylation by FIH regulates the TRPV3 ion channel.
Karttunen S, Duffield M, Scrimgeour NR, Squires L, Lim WL, Dallas ML, Scragg JL, Chicher J, Dave KA, Whitelaw ML, Peers C, Gorman JJ, Gleadle JM, Rychkov GY, Peet DJ. Karttunen S, et al. Among authors: gleadle jm. J Cell Sci. 2015 Jan 15;128(2):225-31. doi: 10.1242/jcs.158451. Epub 2014 Nov 20. J Cell Sci. 2015. PMID: 25413349 Free article.
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.
Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, Mole DR, Mukherji M, Metzen E, Wilson MI, Dhanda A, Tian YM, Masson N, Hamilton DL, Jaakkola P, Barstead R, Hodgkin J, Maxwell PH, Pugh CW, Schofield CJ, Ratcliffe PJ. Epstein AC, et al. Among authors: gleadle jm. Cell. 2001 Oct 5;107(1):43-54. doi: 10.1016/s0092-8674(01)00507-4. Cell. 2001. PMID: 11595184 Free article.
Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family.
Hewitson KS, McNeill LA, Riordan MV, Tian YM, Bullock AN, Welford RW, Elkins JM, Oldham NJ, Bhattacharya S, Gleadle JM, Ratcliffe PJ, Pugh CW, Schofield CJ. Hewitson KS, et al. Among authors: gleadle jm. J Biol Chem. 2002 Jul 19;277(29):26351-5. doi: 10.1074/jbc.C200273200. Epub 2002 May 31. J Biol Chem. 2002. PMID: 12042299 Free article.
The VHL-dependent regulation of microRNAs in renal cancer.
Neal CS, Michael MZ, Rawlings LH, Van der Hoek MB, Gleadle JM. Neal CS, et al. Among authors: gleadle jm. BMC Med. 2010 Oct 21;8:64. doi: 10.1186/1741-7015-8-64. BMC Med. 2010. PMID: 20964835 Free PMC article.
Hypoxia response elements.
O'Rourke JF, Dachs GU, Gleadle JM, Maxwell PH, Pugh CW, Stratford IJ, Wood SM, Ratcliffe PJ. O'Rourke JF, et al. Among authors: gleadle jm. Oncol Res. 1997;9(6-7):327-32. Oncol Res. 1997. PMID: 9406238 Review.
90 results