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Metabolism related toxicity of diclofenac in yeast as model system.
van Leeuwen JS, Vredenburg G, Dragovic S, Tjong TF, Vos JC, Vermeulen NP. van Leeuwen JS, et al. Among authors: vos jc. Toxicol Lett. 2011 Feb 5;200(3):162-8. doi: 10.1016/j.toxlet.2010.11.010. Epub 2010 Nov 24. Toxicol Lett. 2011. PMID: 21111035
Human glutathione S-transferases- and NAD(P)H:quinone oxidoreductase 1-catalyzed inactivation of reactive quinoneimines of amodiaquine and N-desethylamodiaquine: Possible implications for susceptibility to amodiaquine-induced liver toxicity.
Zhang Y, den Braver-Sewradj SP, Vos JC, Vermeulen NPE, Commandeur JNM. Zhang Y, et al. Among authors: vos jc. Toxicol Lett. 2017 Jun 5;275:83-91. doi: 10.1016/j.toxlet.2017.05.003. Epub 2017 May 3. Toxicol Lett. 2017. PMID: 28478157
Reduction and Scavenging of Chemically Reactive Drug Metabolites by NAD(P)H:Quinone Oxidoreductase 1 and NRH:Quinone Oxidoreductase 2 and Variability in Hepatic Concentrations.
den Braver-Sewradj SP, den Braver MW, Toorneman RM, van Leeuwen S, Zhang Y, Dekker SJ, Vermeulen NPE, Commandeur JNM, Vos JC. den Braver-Sewradj SP, et al. Among authors: vos jc. Chem Res Toxicol. 2018 Feb 19;31(2):116-126. doi: 10.1021/acs.chemrestox.7b00289. Epub 2018 Jan 11. Chem Res Toxicol. 2018. PMID: 29281794 Free PMC article.
Direct comparison of UDP-glucuronosyltransferase and cytochrome P450 activities in human liver microsomes, plated and suspended primary human hepatocytes from five liver donors.
den Braver-Sewradj SP, den Braver MW, Baze A, Decorde J, Fonsi M, Bachellier P, Vermeulen NPE, Commandeur JNM, Richert L, Vos JC. den Braver-Sewradj SP, et al. Among authors: vos jc. Eur J Pharm Sci. 2017 Nov 15;109:96-110. doi: 10.1016/j.ejps.2017.07.032. Epub 2017 Aug 1. Eur J Pharm Sci. 2017. PMID: 28778465
51 results