Hett EC - Search Results

1

Rational targeting of active-site tyrosine residues using sulfonyl fluoride probes.

Hett EC, Xu H, Geoghegan KF, Gopalsamy A, Kyne RE Jr, Menard CA, Narayanan A, Parikh MD, Liu S, Roberts L, Robinson RP, Tones MA, Jones LH. Hett EC, et al. ACS Chem Biol. 2015 Apr 17;10(4):1094-8. doi: 10.1021/cb5009475. Epub 2015 Jan 29. ACS Chem Biol. 2015. PMID: 25571984

2

Understanding and applying tyrosine biochemical diversity.

Jones LH, Narayanan A, Hett EC. Jones LH, et al. Among authors: hett ec. Mol Biosyst. 2014 May;10(5):952-69. doi: 10.1039/c4mb00018h. Mol Biosyst. 2014. PMID: 24623162 Review.

3

A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors.

Lanning BR, Whitby LR, Dix MM, Douhan J, Gilbert AM, Hett EC, Johnson TO, Joslyn C, Kath JC, Niessen S, Roberts LR, Schnute ME, Wang C, Hulce JJ, Wei B, Whiteley LO, Hayward MM, Cravatt BF. Lanning BR, et al. Among authors: hett ec. Nat Chem Biol. 2014 Sep;10(9):760-767. doi: 10.1038/nchembio.1582. Epub 2014 Jul 13. Nat Chem Biol. 2014. PMID: 25038787 Free PMC article.

4

A library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpS.

Xu H, Hett EC, Gopalsamy A, Parikh MD, Geoghegan KF, Kyne RE Jr, Menard CA, Narayanan A, Robinson RP, Johnson DS, Tones MA, Jones LH. Xu H, et al. Among authors: hett ec. Mol Biosyst. 2015 Oct;11(10):2709-12. doi: 10.1039/c5mb00288e. Mol Biosyst. 2015. PMID: 25959423

5

Know your target, know your molecule.

Bunnage ME, Gilbert AM, Jones LH, Hett EC. Bunnage ME, et al. Among authors: hett ec. Nat Chem Biol. 2015 Jun;11(6):368-72. doi: 10.1038/nchembio.1813. Nat Chem Biol. 2015. PMID: 25978985 No abstract available.

6

Cellular thermal shift and clickable chemical probe assays for the determination of drug-target engagement in live cells.

Xu H, Gopalsamy A, Hett EC, Salter S, Aulabaugh A, Kyne RE, Pierce B, Jones LH. Xu H, et al. Among authors: hett ec. Org Biomol Chem. 2016 Jul 14;14(26):6179-83. doi: 10.1039/c6ob01078d. Epub 2016 May 24. Org Biomol Chem. 2016. PMID: 27216142

7

Selectivity Determination of a Small Molecule Chemical Probe Using Protein Microarray and Affinity Capture Techniques.

Hett EC, Kyne RE Jr, Gopalsamy A, Tones MA, Xu H, Thio GL, Nolan E, Jones LH. Hett EC, et al. ACS Comb Sci. 2016 Oct 10;18(10):611-615. doi: 10.1021/acscombsci.6b00089. Epub 2016 Aug 17. ACS Comb Sci. 2016. PMID: 27494431

8

Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition.

Telliez JB, Dowty ME, Wang L, Jussif J, Lin T, Li L, Moy E, Balbo P, Li W, Zhao Y, Crouse K, Dickinson C, Symanowicz P, Hegen M, Banker ME, Vincent F, Unwalla R, Liang S, Gilbert AM, Brown MF, Hayward M, Montgomery J, Yang X, Bauman J, Trujillo JI, Casimiro-Garcia A, Vajdos FF, Leung L, Geoghegan KF, Quazi A, Xuan D, Jones L, Hett E, Wright K, Clark JD, Thorarensen A. Telliez JB, et al. ACS Chem Biol. 2016 Dec 16;11(12):3442-3451. doi: 10.1021/acschembio.6b00677. Epub 2016 Nov 10. ACS Chem Biol. 2016. PMID: 27791347

9

Covalent Enzyme Inhibition through Fluorosulfate Modification of a Noncatalytic Serine Residue.

Fadeyi OO, Hoth LR, Choi C, Feng X, Gopalsamy A, Hett EC, Kyne RE Jr, Robinson RP, Jones LH. Fadeyi OO, et al. Among authors: hett ec. ACS Chem Biol. 2017 Aug 18;12(8):2015-2020. doi: 10.1021/acschembio.7b00403. Epub 2017 Jul 20. ACS Chem Biol. 2017. PMID: 28718624

10

Microfluidic-Enabled Intracellular Delivery of Membrane Impermeable Inhibitors to Study Target Engagement in Human Primary Cells.

Li J, Wang B, Juba BM, Vazquez M, Kortum SW, Pierce BS, Pacheco M, Roberts L, Strohbach JW, Jones LH, Hett E, Thorarensen A, Telliez JB, Sharei A, Bunnage M, Gilbert JB. Li J, et al. ACS Chem Biol. 2017 Dec 15;12(12):2970-2974. doi: 10.1021/acschembio.7b00683. Epub 2017 Nov 13. ACS Chem Biol. 2017. PMID: 29088528

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