Xu H - Search Results

1

Rational targeting of active-site tyrosine residues using sulfonyl fluoride probes.

Hett EC, Xu H, Geoghegan KF, Gopalsamy A, Kyne RE Jr, Menard CA, Narayanan A, Parikh MD, Liu S, Roberts L, Robinson RP, Tones MA, Jones LH. Hett EC, et al. Among authors: xu h. ACS Chem Biol. 2015 Apr 17;10(4):1094-8. doi: 10.1021/cb5009475. Epub 2015 Jan 29. ACS Chem Biol. 2015. PMID: 25571984

2

A library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpS.

Xu H, Hett EC, Gopalsamy A, Parikh MD, Geoghegan KF, Kyne RE Jr, Menard CA, Narayanan A, Robinson RP, Johnson DS, Tones MA, Jones LH. Xu H, et al. Mol Biosyst. 2015 Oct;11(10):2709-12. doi: 10.1039/c5mb00288e. Mol Biosyst. 2015. PMID: 25959423

3

Cellular thermal shift and clickable chemical probe assays for the determination of drug-target engagement in live cells.

Xu H, Gopalsamy A, Hett EC, Salter S, Aulabaugh A, Kyne RE, Pierce B, Jones LH. Xu H, et al. Org Biomol Chem. 2016 Jul 14;14(26):6179-83. doi: 10.1039/c6ob01078d. Epub 2016 May 24. Org Biomol Chem. 2016. PMID: 27216142

4

Selectivity Determination of a Small Molecule Chemical Probe Using Protein Microarray and Affinity Capture Techniques.

Hett EC, Kyne RE Jr, Gopalsamy A, Tones MA, Xu H, Thio GL, Nolan E, Jones LH. Hett EC, et al. Among authors: xu h. ACS Comb Sci. 2016 Oct 10;18(10):611-615. doi: 10.1021/acscombsci.6b00089. Epub 2016 Aug 17. ACS Comb Sci. 2016. PMID: 27494431

5

Quantifying drug-target engagement in live cells using sulfonyl fluoride chemical probes.

Jones LH, Xu H, Fadeyi OO. Jones LH, et al. Among authors: xu h. Methods Enzymol. 2019;622:201-220. doi: 10.1016/bs.mie.2019.02.010. Epub 2019 Mar 9. Methods Enzymol. 2019. PMID: 31155053

6

Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists.

Liu S, Dakin LA, Xing L, Withka JM, Sahasrabudhe PV, Li W, Banker ME, Balbo P, Shanker S, Chrunyk BA, Guo Z, Chen JM, Young JA, Bai G, Starr JT, Wright SW, Bussenius J, Tan S, Gopalsamy A, Lefker BA, Vincent F, Jones LH, Xu H, Hoth LR, Geoghegan KF, Qiu X, Bunnage ME, Thorarensen A. Liu S, et al. Among authors: xu h. Sci Rep. 2016 Aug 16;6:30859. doi: 10.1038/srep30859. Sci Rep. 2016. PMID: 27527709 Free PMC article.

7

Quantitative measurement of intracellular HDAC1/2 drug occupancy using a trans-cyclooctene largazole thiol probe.

Xu H, Roberts LR, Chou S, Pierce B, Narayanan A, Jones LH. Xu H, et al. Medchemcomm. 2017 Jan 9;8(4):767-770. doi: 10.1039/c6md00633g. eCollection 2017 Apr 1. Medchemcomm. 2017. PMID: 30108795 Free PMC article.

8

Click chemistry patents and their impact on drug discovery and chemical biology.

Xu H, Jones LH. Xu H, et al. Pharm Pat Anal. 2015;4(2):109-19. doi: 10.4155/ppa.14.59. Pharm Pat Anal. 2015. PMID: 25853470 Review.

9

PF-06651600, a Dual JAK3/TEC Family Kinase Inhibitor.

Xu H, Jesson MI, Seneviratne UI, Lin TH, Sharif MN, Xue L, Nguyen C, Everley RA, Trujillo JI, Johnson DS, Point GR, Thorarensen A, Kilty I, Telliez JB. Xu H, et al. ACS Chem Biol. 2019 Jun 21;14(6):1235-1242. doi: 10.1021/acschembio.9b00188. Epub 2019 May 22. ACS Chem Biol. 2019. PMID: 31082193

10

Fluorophosphonate-Based Degrader Identifies Degradable Serine Hydrolases by Quantitative Proteomics.

Field SD, Lee W, Dutra JK, Serneo FSF, Oyer J, Xu H, Johnson DS, Am Ende CW, Seneviratne U. Field SD, et al. Among authors: xu h. Chembiochem. 2020 Oct 15;21(20):2916-2920. doi: 10.1002/cbic.202000253. Epub 2020 Jul 23. Chembiochem. 2020. PMID: 32501609

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