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A novel selective and orally bioavailable Nav 1.8 channel blocker, PF-01247324, attenuates nociception and sensory neuron excitability.
Br J Pharmacol. 2015 May;172(10):2654-70. doi: 10.1111/bph.13092. Epub 2015 Apr 10.
Br J Pharmacol. 2015.
PMID: 25625641
Free PMC article.
GI-530159, a novel, selective, mechanosensitive two-pore-domain potassium (K2P ) channel opener, reduces rat dorsal root ganglion neuron excitability.
Loucif AJC, Saintot PP, Liu J, Antonio BM, Zellmer SG, Yoger K, Veale EL, Wilbrey A, Omoto K, Cao L, Gutteridge A, Castle NA, Stevens EB, Mathie A.
Loucif AJC, et al.
Br J Pharmacol. 2018 Jun;175(12):2272-2283. doi: 10.1111/bph.14098. Epub 2017 Dec 29.
Br J Pharmacol. 2018.
PMID: 29150838
Free PMC article.
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Pharmacological reversal of a pain phenotype in iPSC-derived sensory neurons and patients with inherited erythromelalgia.
Cao L, McDonnell A, Nitzsche A, Alexandrou A, Saintot PP, Loucif AJ, Brown AR, Young G, Mis M, Randall A, Waxman SG, Stanley P, Kirby S, Tarabar S, Gutteridge A, Butt R, McKernan RM, Whiting P, Ali Z, Bilsland J, Stevens EB.
Cao L, et al. Among authors: loucif aj.
Sci Transl Med. 2016 Apr 20;8(335):335ra56. doi: 10.1126/scitranslmed.aad7653.
Sci Transl Med. 2016.
PMID: 27099175
Clinical Trial.
Item in Clipboard
Depolarisation and suppression of burst firing activity in the mouse subthalamic nucleus by dopamine D1/D5 receptor activation of a cyclic-nucleotide gated non-specific cation conductance.
Loucif AJ, Woodhall GL, Sehirli US, Stanford IM.
Loucif AJ, et al.
Neuropharmacology. 2008 Jul;55(1):94-105. doi: 10.1016/j.neuropharm.2008.04.025. Epub 2008 May 14.
Neuropharmacology. 2008.
PMID: 18547595
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Publisher Correction: Molecular and functional variation in iPSC-derived sensory neurons.
Schwartzentruber J, Foskolou S, Kilpinen H, Rodrigues J, Alasoo K, Knights AJ, Patel M, Goncalves A, Ferreira R, Benn CL, Wilbrey A, Bictash M, Impey E, Cao L, Lainez S, Loucif AJ, Whiting PJ; HIPSCI Consortium; Gutteridge A, Gaffney DJ.
Schwartzentruber J, et al. Among authors: loucif aj.
Nat Genet. 2019 Jul;51(7):1190. doi: 10.1038/s41588-019-0445-4.
Nat Genet. 2019.
PMID: 31160811
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Molecular and functional variation in iPSC-derived sensory neurons.
Schwartzentruber J, Foskolou S, Kilpinen H, Rodrigues J, Alasoo K, Knights AJ, Patel M, Goncalves A, Ferreira R, Benn CL, Wilbrey A, Bictash M, Impey E, Cao L, Lainez S, Loucif AJ, Whiting PJ; HIPSCI Consortium; Gutteridge A, Gaffney DJ.
Schwartzentruber J, et al. Among authors: loucif aj.
Nat Genet. 2018 Jan;50(1):54-61. doi: 10.1038/s41588-017-0005-8. Epub 2017 Dec 11.
Nat Genet. 2018.
PMID: 29229984
Free PMC article.
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Morphological Characteristics of Electrophysiologically Characterized Layer Vb Pyramidal Cells in Rat Barrel Cortex.
Staiger JF, Loucif AJ, Schubert D, Möck M.
Staiger JF, et al. Among authors: loucif aj.
PLoS One. 2016 Oct 5;11(10):e0164004. doi: 10.1371/journal.pone.0164004. eCollection 2016.
PLoS One. 2016.
PMID: 27706253
Free PMC article.
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Gender-dependent regulation of G-protein-gated inwardly rectifying potassium current in dorsal raphe neurons in knock-out mice devoid of the 5-hydroxytryptamine transporter.
Loucif AJ, Bonnavion P, Macri B, Golmard JL, Boni C, Melfort M, Leonard G, Lesch KP, Adrien J, Jacquin TD.
Loucif AJ, et al.
J Neurobiol. 2006 Nov;66(13):1475-88. doi: 10.1002/neu.20321.
J Neurobiol. 2006.
PMID: 17013926
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