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Notch pathway activation targets AML-initiating cell homeostasis and differentiation.
Lobry C, Ntziachristos P, Ndiaye-Lobry D, Oh P, Cimmino L, Zhu N, Araldi E, Hu W, Freund J, Abdel-Wahab O, Ibrahim S, Skokos D, Armstrong SA, Levine RL, Park CY, Aifantis I. Lobry C, et al. Among authors: cimmino l. J Exp Med. 2013 Feb 11;210(2):301-19. doi: 10.1084/jem.20121484. Epub 2013 Jan 28. J Exp Med. 2013. PMID: 23359070 Free PMC article.
Stage-specific control of early B cell development by the transcription factor Ikaros.
Schwickert TA, Tagoh H, Gültekin S, Dakic A, Axelsson E, Minnich M, Ebert A, Werner B, Roth M, Cimmino L, Dickins RA, Zuber J, Jaritz M, Busslinger M. Schwickert TA, et al. Among authors: cimmino l. Nat Immunol. 2014 Mar;15(3):283-93. doi: 10.1038/ni.2828. Epub 2014 Feb 9. Nat Immunol. 2014. PMID: 24509509 Free PMC article.
TET1 is a tumor suppressor of hematopoietic malignancy.
Cimmino L, Dawlaty MM, Ndiaye-Lobry D, Yap YS, Bakogianni S, Yu Y, Bhattacharyya S, Shaknovich R, Geng H, Lobry C, Mullenders J, King B, Trimarchi T, Aranda-Orgilles B, Liu C, Shen S, Verma AK, Jaenisch R, Aifantis I. Cimmino L, et al. Nat Immunol. 2015 Jun;16(6):653-62. doi: 10.1038/ni.3148. Epub 2015 Apr 13. Nat Immunol. 2015. PMID: 25867473 Free PMC article.
Cohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasms.
Mullenders J, Aranda-Orgilles B, Lhoumaud P, Keller M, Pae J, Wang K, Kayembe C, Rocha PP, Raviram R, Gong Y, Premsrirut PK, Tsirigos A, Bonneau R, Skok JA, Cimmino L, Hoehn D, Aifantis I. Mullenders J, et al. Among authors: cimmino l. J Exp Med. 2015 Oct 19;212(11):1833-50. doi: 10.1084/jem.20151323. Epub 2015 Oct 5. J Exp Med. 2015. PMID: 26438359 Free PMC article.
The Impact of DNA Methylation in Hematopoietic Malignancies.
Guillamot M, Cimmino L, Aifantis I. Guillamot M, et al. Among authors: cimmino l. Trends Cancer. 2016 Feb 1;2(2):70-83. doi: 10.1016/j.trecan.2015.12.006. Trends Cancer. 2016. PMID: 27019871 Free PMC article.
Alternative roles for oxidized mCs and TETs.
Cimmino L, Aifantis I. Cimmino L, et al. Curr Opin Genet Dev. 2017 Feb;42:1-7. doi: 10.1016/j.gde.2016.11.003. Epub 2016 Dec 7. Curr Opin Genet Dev. 2017. PMID: 27939598 Free PMC article. Review.
73 results