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Dual PI3K/mTOR Inhibitors Induce Rapid Overactivation of the MEK/ERK Pathway in Human Pancreatic Cancer Cells through Suppression of mTORC2.
Mol Cancer Ther. 2015 Apr;14(4):1014-23. doi: 10.1158/1535-7163.MCT-14-0669. Epub 2015 Feb 11.
Mol Cancer Ther. 2015.
PMID: 25673820
Free PMC article.
Suppression of feedback loops mediated by PI3K/mTOR induces multiple overactivation of compensatory pathways: an unintended consequence leading to drug resistance.
Rozengurt E, Soares HP, Sinnet-Smith J.
Rozengurt E, et al. Among authors: sinnet smith j.
Mol Cancer Ther. 2014 Nov;13(11):2477-88. doi: 10.1158/1535-7163.MCT-14-0330. Epub 2014 Oct 16.
Mol Cancer Ther. 2014.
PMID: 25323681
Free PMC article.
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