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Synthesis and Evaluation of Heterocyclic Catechol Mimics as Inhibitors of Catechol-O-methyltransferase (COMT).
ACS Med Chem Lett. 2015 Jan 26;6(3):318-23. doi: 10.1021/ml500502d. eCollection 2015 Mar 12.
ACS Med Chem Lett. 2015.
PMID: 25815153
Free PMC article.
Synthesis and evaluation of a new series of Neuropeptide S receptor antagonists.
Melamed JY, Zartman AE, Kett NR, Gotter AL, Uebele VN, Reiss DR, Condra CL, Fandozzi C, Lubbers LS, Rowe BA, McGaughey GB, Henault M, Stocco R, Renger JJ, Hartman GD, Bilodeau MT, Trotter BW.
Melamed JY, et al.
Bioorg Med Chem Lett. 2010 Aug 1;20(15):4700-3. doi: 10.1016/j.bmcl.2010.04.143. Epub 2010 May 5.
Bioorg Med Chem Lett. 2010.
PMID: 20510609
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Synthesis of 5-(1-H or 1-alkyl-5-oxopyrrolidin-3-yl)-8-hydroxy-[1,6]-naphthyridine-7-carboxamide inhibitors of HIV-1 integrase.
Melamed JY, Egbertson MS, Varga S, Vacca JP, Moyer G, Gabryelski L, Felock PJ, Stillmock KA, Witmer MV, Schleif W, Hazuda DJ, Leonard Y, Jin L, Ellis JD, Young SD.
Melamed JY, et al.
Bioorg Med Chem Lett. 2008 Oct 1;18(19):5307-10. doi: 10.1016/j.bmcl.2008.08.038. Epub 2008 Aug 14.
Bioorg Med Chem Lett. 2008.
PMID: 18774711
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4-Aryl-2,4-dioxobutanoic acid inhibitors of HIV-1 integrase and viral replication in cells.
Wai JS, Egbertson MS, Payne LS, Fisher TE, Embrey MW, Tran LO, Melamed JY, Langford HM, Guare JP Jr, Zhuang L, Grey VE, Vacca JP, Holloway MK, Naylor-Olsen AM, Hazuda DJ, Felock PJ, Wolfe AL, Stillmock KA, Schleif WA, Gabryelski LJ, Young SD.
Wai JS, et al. Among authors: melamed jy.
J Med Chem. 2000 Dec 28;43(26):4923-6. doi: 10.1021/jm000176b.
J Med Chem. 2000.
PMID: 11150161
No abstract available.
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A potent and orally active HIV-1 integrase inhibitor.
Egbertson MS, Moritz HM, Melamed JY, Han W, Perlow DS, Kuo MS, Embrey M, Vacca JP, Zrada MM, Cortes AR, Wallace A, Leonard Y, Hazuda DJ, Miller MD, Felock PJ, Stillmock KA, Witmer MV, Schleif W, Gabryelski LJ, Moyer G, Ellis JD, Jin L, Xu W, Braun MP, Kassahun K, Tsou NN, Young SD.
Egbertson MS, et al. Among authors: melamed jy.
Bioorg Med Chem Lett. 2007 Mar 1;17(5):1392-8. doi: 10.1016/j.bmcl.2006.11.080. Epub 2006 Dec 3.
Bioorg Med Chem Lett. 2007.
PMID: 17194584
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HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase.
Espeseth AS, Felock P, Wolfe A, Witmer M, Grobler J, Anthony N, Egbertson M, Melamed JY, Young S, Hamill T, Cole JL, Hazuda DJ.
Espeseth AS, et al. Among authors: melamed jy.
Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11244-9. doi: 10.1073/pnas.200139397.
Proc Natl Acad Sci U S A. 2000.
PMID: 11016953
Free PMC article.
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Diketo acid inhibitor mechanism and HIV-1 integrase: implications for metal binding in the active site of phosphotransferase enzymes.
Grobler JA, Stillmock K, Hu B, Witmer M, Felock P, Espeseth AS, Wolfe A, Egbertson M, Bourgeois M, Melamed J, Wai JS, Young S, Vacca J, Hazuda DJ.
Grobler JA, et al.
Proc Natl Acad Sci U S A. 2002 May 14;99(10):6661-6. doi: 10.1073/pnas.092056199. Epub 2002 May 7.
Proc Natl Acad Sci U S A. 2002.
PMID: 11997448
Free PMC article.
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Total synthesis of (-)-normalindine via addition of metalated 4-methyl-3-cyanopyridine to an enantiopure sulfinimine.
Davis FA, Melamed JY, Sharik SS.
Davis FA, et al. Among authors: melamed jy.
J Org Chem. 2006 Nov 10;71(23):8761-6. doi: 10.1021/jo061443+.
J Org Chem. 2006.
PMID: 17081004
Free PMC article.
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