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Using available in vitro metabolite identification and time course kinetics for β-chloroprene and its metabolite, (1-chloroethenyl) oxirane, to include reactive oxidative metabolites and glutathione depletion in a PBPK model for β-chloroprene.
Campbell JL Jr, Clewell HJ 3rd, Van Landingham C, Gentry PR, Andersen ME. Campbell JL Jr, et al. Among authors: gentry pr. Front Pharmacol. 2023 Aug 17;14:1223808. doi: 10.3389/fphar.2023.1223808. eCollection 2023. Front Pharmacol. 2023. PMID: 37663267 Free PMC article.
Identification of a Novel Allosteric Site at the M5 Muscarinic Acetylcholine Receptor.
Burger WAC, Gentry PR, Berizzi AE, Vuckovic Z, van der Westhuizen ET, Thompson G, Yeasmin M, Lindsley CW, Sexton PM, Langmead CJ, Tobin AB, Christopoulos A, Valant C, Thal DM. Burger WAC, et al. Among authors: gentry pr. ACS Chem Neurosci. 2021 Aug 18;12(16):3112-3123. doi: 10.1021/acschemneuro.1c00383. Epub 2021 Aug 5. ACS Chem Neurosci. 2021. PMID: 34351123
93 results