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AXL mediates resistance to PI3Kα inhibition by activating the EGFR/PKC/mTOR axis in head and neck and esophageal squamous cell carcinomas.
Elkabets M, Pazarentzos E, Juric D, Sheng Q, Pelossof RA, Brook S, Benzaken AO, Rodon J, Morse N, Yan JJ, Liu M, Das R, Chen Y, Tam A, Wang H, Liang J, Gurski JM, Kerr DA, Rosell R, Teixidó C, Huang A, Ghossein RA, Rosen N, Bivona TG, Scaltriti M, Baselga J. Elkabets M, et al. Among authors: pelossof ra. Cancer Cell. 2015 Apr 13;27(4):533-46. doi: 10.1016/j.ccell.2015.03.010. Cancer Cell. 2015. PMID: 25873175 Free PMC article.
KRAS mutant rectal cancer cells interact with surrounding fibroblasts to deplete the extracellular matrix.
Kim JK, Marco MR, Choi SH, Qu X, Chen CT, Elkabets M, Fairchild L, Chow O, Barriga FM, Dow LE, O'Rourke K, Szeglin B, Yarilin D, Fujisawa S, Manova-Todorova K, Paty PB, Shia J, Leslie C, Smith JJ, Lowe S, Pelossof R, Sanchez-Vega F, Garcia-Aguilar J. Kim JK, et al. Mol Oncol. 2021 Oct;15(10):2766-2781. doi: 10.1002/1878-0261.12960. Epub 2021 Jun 15. Mol Oncol. 2021. PMID: 33817986 Free PMC article.
KRAS and Combined KRAS/TP53 Mutations in Locally Advanced Rectal Cancer are Independently Associated with Decreased Response to Neoadjuvant Therapy.
Chow OS, Kuk D, Keskin M, Smith JJ, Camacho N, Pelossof R, Chen CT, Chen Z, Avila K, Weiser MR, Berger MF, Patil S, Bergsland E, Garcia-Aguilar J. Chow OS, et al. Ann Surg Oncol. 2016 Aug;23(8):2548-55. doi: 10.1245/s10434-016-5205-4. Epub 2016 Mar 28. Ann Surg Oncol. 2016. PMID: 27020587 Free PMC article. Clinical Trial.
Genomic and transcriptomic determinants of response to neoadjuvant therapy in rectal cancer.
Chatila WK, Kim JK, Walch H, Marco MR, Chen CT, Wu F, Omer DM, Khalil DN, Ganesh K, Qu X, Luthra A, Choi SH, Ho YJ, Kundra R, Groves KI, Chow OS, Cercek A, Weiser MR, Widmar M, Wei IH, Pappou EP, Nash GM, Paty PB, Shi Q, Vakiani E, Duygu Selcuklu S, Donoghue MTA, Solit DB, Berger MF, Shia J, Pelossof R, Romesser PB, Yaeger R, Smith JJ, Schultz N, Sanchez-Vega F, Garcia-Aguilar J. Chatila WK, et al. Nat Med. 2022 Aug;28(8):1646-1655. doi: 10.1038/s41591-022-01930-z. Epub 2022 Aug 15. Nat Med. 2022. PMID: 35970919 Free PMC article.
18 results