Cole PA - Search Results

1

The epigenetic regulators CBP and p300 facilitate leukemogenesis and represent therapeutic targets in acute myeloid leukemia.

Giotopoulos G, Chan WI, Horton SJ, Ruau D, Gallipoli P, Fowler A, Crawley C, Papaemmanuil E, Campbell PJ, Göttgens B, Van Deursen JM, Cole PA, Huntly BJ. Giotopoulos G, et al. Among authors: cole pa. Oncogene. 2016 Jan 21;35(3):279-89. doi: 10.1038/onc.2015.92. Epub 2015 Apr 20. Oncogene. 2016. PMID: 25893291 Free PMC article.

2

LSD1 Histone Demethylase Assays and Inhibition.

Hayward D, Cole PA. Hayward D, et al. Among authors: cole pa. Methods Enzymol. 2016;573:261-78. doi: 10.1016/bs.mie.2016.01.020. Epub 2016 Feb 23. Methods Enzymol. 2016. PMID: 27372757 Free PMC article. Review.

3

Phase I dose escalation and pharmacokinetic study of enzastaurin, an oral protein kinase C beta inhibitor, in patients with advanced cancer.

Carducci MA, Musib L, Kies MS, Pili R, Truong M, Brahmer JR, Cole P, Sullivan R, Riddle J, Schmidt J, Enas N, Sinha V, Thornton DE, Herbst RS. Carducci MA, et al. J Clin Oncol. 2006 Sep 1;24(25):4092-9. doi: 10.1200/JCO.2005.05.3447. J Clin Oncol. 2006. PMID: 16943527 Clinical Trial.

4

Sulphoxythiocarbamates modify cysteine residues in HSP90 causing degradation of client proteins and inhibition of cancer cell proliferation.

Zhang Y, Dayalan Naidu S, Samarasinghe K, Van Hecke GC, Pheely A, Boronina TN, Cole RN, Benjamin IJ, Cole PA, Ahn YH, Dinkova-Kostova AT. Zhang Y, et al. Among authors: cole rn, cole pa. Br J Cancer. 2014 Jan 7;110(1):71-82. doi: 10.1038/bjc.2013.710. Epub 2013 Dec 5. Br J Cancer. 2014. PMID: 24322890 Free PMC article.

5

Site-specific incorporation of a phosphotyrosine mimetic reveals a role for tyrosine phosphorylation of SHP-2 in cell signaling.

Lu W, Gong D, Bar-Sagi D, Cole PA. Lu W, et al. Among authors: cole pa. Mol Cell. 2001 Oct;8(4):759-69. doi: 10.1016/s1097-2765(01)00369-0. Mol Cell. 2001. PMID: 11684012 Free article.

6

Mechanism and inhibition of cytochrome P-450 aromatase.

Cole PA, Robinson CH. Cole PA, et al. J Med Chem. 1990 Nov;33(11):2933-42. doi: 10.1021/jm00173a001. J Med Chem. 1990. PMID: 2231592 Review. No abstract available.

7

Conversion of a 3-desoxysteroid to 3-desoxyestrogen by human placental aromatase.

Cole PA, Bean JM, Robinson CH. Cole PA, et al. Proc Natl Acad Sci U S A. 1990 Apr;87(8):2999-3003. doi: 10.1073/pnas.87.8.2999. Proc Natl Acad Sci U S A. 1990. PMID: 2326261 Free PMC article.

8

Conversion of 19-oxo[2 beta-2H]androgens into oestrogens by human placental aromatase. An unexpected stereochemical outcome.

Cole PA, Robinson CH. Cole PA, et al. Biochem J. 1990 Jun 15;268(3):553-61. doi: 10.1042/bj2680553. Biochem J. 1990. PMID: 2363692 Free PMC article.

9

The CoREST complex is a therapeutic vulnerability in malignant peripheral nerve sheath tumors.

Soukar I, Fisher R, Bhagavatula S, Collard M, Cole PA, Alani RM. Soukar I, et al. Among authors: cole pa. bioRxiv [Preprint]. 2024 Aug 19:2024.08.17.607802. doi: 10.1101/2024.08.17.607802. bioRxiv. 2024. PMID: 39229179 Free PMC article. Preprint.

10

Multifaceted regulation of Sirtuin 2 (Sirt2) Deacetylase Activity.

Abeywardana MY, Whedon SD, Lee K, Nam E, Dovarganes R, Dubois-Coyne S, Haque IA, Wang ZA, Cole PA. Abeywardana MY, et al. Among authors: cole pa. J Biol Chem. 2024 Aug 28:107722. doi: 10.1016/j.jbc.2024.107722. Online ahead of print. J Biol Chem. 2024. PMID: 39214297 Free article.

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