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Page 1
Enhancing the antitumor efficacy of a cell-surface death ligand by covalent membrane display.
Nair PM, Flores H, Gogineni A, Marsters S, Lawrence DA, Kelley RF, Ngu H, Sagolla M, Komuves L, Bourgon R, Settleman J, Ashkenazi A. Nair PM, et al. Among authors: sagolla m. Proc Natl Acad Sci U S A. 2015 May 5;112(18):5679-84. doi: 10.1073/pnas.1418962112. Epub 2015 Apr 20. Proc Natl Acad Sci U S A. 2015. PMID: 25902490 Free PMC article.
Disruption of PH-kinase domain interactions leads to oncogenic activation of AKT in human cancers.
Parikh C, Janakiraman V, Wu WI, Foo CK, Kljavin NM, Chaudhuri S, Stawiski E, Lee B, Lin J, Li H, Lorenzo MN, Yuan W, Guillory J, Jackson M, Rondon J, Franke Y, Bowman KK, Sagolla M, Stinson J, Wu TD, Wu J, Stokoe D, Stern HM, Brandhuber BJ, Lin K, Skelton NJ, Seshagiri S. Parikh C, et al. Among authors: sagolla m. Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19368-73. doi: 10.1073/pnas.1204384109. Epub 2012 Nov 7. Proc Natl Acad Sci U S A. 2012. PMID: 23134728 Free PMC article.
Unstable Mechanisms of Resistance to Inhibitors of Escherichia coli Lipoprotein Signal Peptidase.
Pantua H, Skippington E, Braun MG, Noland CL, Diao J, Peng Y, Gloor SL, Yan D, Kang J, Katakam AK, Reeder J, Castanedo GM, Garland K, Komuves L, Sagolla M, Austin CD, Murray J, Xu Y, Modrusan Z, Xu M, Hanan EJ, Kapadia SB. Pantua H, et al. Among authors: sagolla m. mBio. 2020 Sep 8;11(5):e02018-20. doi: 10.1128/mBio.02018-20. mBio. 2020. PMID: 32900806 Free PMC article.
A WISP1 antibody inhibits MRTF signaling to prevent the progression of established liver fibrosis.
Xi Y, LaCanna R, Ma HY, N'Diaye EN, Gierke S, Caplazi P, Sagolla M, Huang Z, Lucio L, Arlantico A, Jeet S, Brightbill H, Emson C, Wong A, Morshead KB, DePianto DJ, Roose-Girma M, Yu C, Tam L, Jia G, Ramalingam TR, Marsters S, Ashkenazi A, Kim SH, Kelly R, Wu S, Wolters PJ, Feldstein AE, Vander Heiden JA, Ding N. Xi Y, et al. Among authors: sagolla m. Cell Metab. 2022 Sep 6;34(9):1377-1393.e8. doi: 10.1016/j.cmet.2022.07.009. Epub 2022 Aug 19. Cell Metab. 2022. PMID: 35987202 Free article.
Lipid nanoparticle delivery limits antisense oligonucleotide activity and cellular distribution in the brain after intracerebroventricular injection.
Byrnes AE, Dominguez SL, Yen CW, Laufer BI, Foreman O, Reichelt M, Lin H, Sagolla M, Hötzel K, Ngu H, Soendergaard C, Estevez A, Lin HC, Goyon A, Bian J, Lin J, Hinz FI, Friedman BA, Easton A, Hoogenraad CC. Byrnes AE, et al. Among authors: sagolla m. Mol Ther Nucleic Acids. 2023 May 9;32:773-793. doi: 10.1016/j.omtn.2023.05.005. eCollection 2023 Jun 13. Mol Ther Nucleic Acids. 2023. PMID: 37346977 Free PMC article.
NINJ1 mediates plasma membrane rupture during lytic cell death.
Kayagaki N, Kornfeld OS, Lee BL, Stowe IB, O'Rourke K, Li Q, Sandoval W, Yan D, Kang J, Xu M, Zhang J, Lee WP, McKenzie BS, Ulas G, Payandeh J, Roose-Girma M, Modrusan Z, Reja R, Sagolla M, Webster JD, Cho V, Andrews TD, Morris LX, Miosge LA, Goodnow CC, Bertram EM, Dixit VM. Kayagaki N, et al. Among authors: sagolla m. Nature. 2021 Mar;591(7848):131-136. doi: 10.1038/s41586-021-03218-7. Epub 2021 Jan 20. Nature. 2021. PMID: 33472215
Deletion of a previously uncharacterized lipoprotein lirL confers resistance to an inhibitor of type II signal peptidase in Acinetobacter baumannii.
Huang KJ, Pantua H, Diao J, Skippington E, Volny M, Sandoval W, Tiku V, Peng Y, Sagolla M, Yan D, Kang J, Katakam AK, Michaelian N, Reichelt M, Tan MW, Austin CD, Xu M, Hanan E, Kapadia SB. Huang KJ, et al. Among authors: sagolla m. Proc Natl Acad Sci U S A. 2022 Sep 20;119(38):e2123117119. doi: 10.1073/pnas.2123117119. Epub 2022 Sep 13. Proc Natl Acad Sci U S A. 2022. PMID: 36099298 Free PMC article.
Activity of caspase-8 determines plasticity between cell death pathways.
Newton K, Wickliffe KE, Maltzman A, Dugger DL, Reja R, Zhang Y, Roose-Girma M, Modrusan Z, Sagolla MS, Webster JD, Dixit VM. Newton K, et al. Among authors: sagolla ms. Nature. 2019 Nov;575(7784):679-682. doi: 10.1038/s41586-019-1752-8. Epub 2019 Nov 13. Nature. 2019. PMID: 31723262
30 results