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Inflammatory and age-related pathologies in mice with ectopic expression of human PARP-1.
Mangerich A, Herbach N, Hanf B, Fischbach A, Popp O, Moreno-Villanueva M, Bruns OT, Bürkle A. Mangerich A, et al. Among authors: burkle a. Mech Ageing Dev. 2010 Jun;131(6):389-404. doi: 10.1016/j.mad.2010.05.005. Epub 2010 Jun 8. Mech Ageing Dev. 2010. PMID: 20561897
PARP-1 is involved in the regulation of genomic integrity, transcription, inflammation, and cell death. Due to its versatile role, PARP-1 is discussed both as a longevity factor and as an aging-promoting factor. Recently, we generated a mouse model with ectopic inte …
PARP-1 is involved in the regulation of genomic integrity, transcription, inflammation, and cell death. Due to its versatile role, PARP-1 is …
Multiparameter toxicity assessment of novel DOPO-derived organophosphorus flame retardants.
Hirsch C, Striegl B, Mathes S, Adlhart C, Edelmann M, Bono E, Gaan S, Salmeia KA, Hoelting L, Krebs A, Nyffeler J, Pape R, Bürkle A, Leist M, Wick P, Schildknecht S. Hirsch C, et al. Among authors: burkle a. Arch Toxicol. 2017 Jan;91(1):407-425. doi: 10.1007/s00204-016-1680-4. Epub 2016 Feb 29. Arch Toxicol. 2017. PMID: 26928308 Free PMC article.
Opportunities for the repurposing of PARP inhibitors for the therapy of non-oncological diseases.
Berger NA, Besson VC, Boulares AH, Bürkle A, Chiarugi A, Clark RS, Curtin NJ, Cuzzocrea S, Dawson TM, Dawson VL, Haskó G, Liaudet L, Moroni F, Pacher P, Radermacher P, Salzman AL, Snyder SH, Soriano FG, Strosznajder RP, Sümegi B, Swanson RA, Szabo C. Berger NA, et al. Among authors: burkle a. Br J Pharmacol. 2018 Jan;175(2):192-222. doi: 10.1111/bph.13748. Epub 2017 Mar 26. Br J Pharmacol. 2018. PMID: 28213892 Free PMC article. Review.
Poly(ADP-ribosyl)ation, PARP, and aging.
Beneke S, Bürkle A. Beneke S, et al. Among authors: burkle a. Sci Aging Knowledge Environ. 2004 Dec 8;2004(49):re9. doi: 10.1126/sageke.2004.49.re9. Sci Aging Knowledge Environ. 2004. PMID: 15590998 Review.
257 results