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Altered functional brain network connectivity and glutamate system function in transgenic mice expressing truncated Disrupted-in-Schizophrenia 1.
Dawson N, Kurihara M, Thomson DM, Winchester CL, McVie A, Hedde JR, Randall AD, Shen S, Seymour PA, Hughes ZA, Dunlop J, Brown JT, Brandon NJ, Morris BJ, Pratt JA. Dawson N, et al. Among authors: hughes za. Transl Psychiatry. 2015 May 19;5(5):e569. doi: 10.1038/tp.2015.60. Transl Psychiatry. 2015. PMID: 25989143 Free PMC article.
FBXW7 regulates DISC1 stability via the ubiquitin-proteosome system.
Yalla K, Elliott C, Day JP, Findlay J, Barratt S, Hughes ZA, Wilson L, Whiteley E, Popiolek M, Li Y, Dunlop J, Killick R, Adams DR, Brandon NJ, Houslay MD, Hao B, Baillie GS. Yalla K, et al. Among authors: hughes za. Mol Psychiatry. 2018 May;23(5):1278-1286. doi: 10.1038/mp.2017.138. Epub 2017 Jul 20. Mol Psychiatry. 2018. PMID: 28727686 Free PMC article.
Future viable models of psychiatry drug discovery in pharma.
Rizzo SJ, Edgerton JR, Hughes ZA, Brandon NJ. Rizzo SJ, et al. Among authors: hughes za. J Biomol Screen. 2013 Jun;18(5):509-21. doi: 10.1177/1087057113475871. Epub 2013 Feb 7. J Biomol Screen. 2013. PMID: 23392517 Review.
Verbal working memory and functional large-scale networks in schizophrenia.
Dauvermann MR, Moorhead TW, Watson AR, Duff B, Romaniuk L, Hall J, Roberts N, Lee GL, Hughes ZA, Brandon NJ, Whitcher B, Blackwood DH, McIntosh AM, Lawrie SM. Dauvermann MR, et al. Among authors: hughes za. Psychiatry Res Neuroimaging. 2017 Dec 30;270:86-96. doi: 10.1016/j.pscychresns.2017.10.004. Epub 2017 Oct 23. Psychiatry Res Neuroimaging. 2017. PMID: 29111478 Free article.
Balanced translocation linked to psychiatric disorder, glutamate, and cortical structure/function.
Thomson PA, Duff B, Blackwood DH, Romaniuk L, Watson A, Whalley HC, Li X, Dauvermann MR, Moorhead TW, Bois C, Ryan NM, Redpath H, Hall L, Morris SW, van Beek EJ, Roberts N, Porteous DJ, St Clair D, Whitcher B, Dunlop J, Brandon NJ, Hughes ZA, Hall J, McIntosh A, Lawrie SM. Thomson PA, et al. Among authors: hughes za. NPJ Schizophr. 2016 Aug 10;2:16024. doi: 10.1038/npjschz.2016.24. eCollection 2016. NPJ Schizophr. 2016. PMID: 27602385 Free PMC article.
Negative allosteric modulation of metabotropic glutamate receptor 5 results in broad spectrum activity relevant to treatment resistant depression.
Hughes ZA, Neal SJ, Smith DL, Sukoff Rizzo SJ, Pulicicchio CM, Lotarski S, Lu S, Dwyer JM, Brennan J, Olsen M, Bender CN, Kouranova E, Andree TH, Harrison JE, Whiteside GT, Springer D, O'Neil SV, Leonard SK, Schechter LE, Dunlop J, Rosenzweig-Lipson S, Ring RH. Hughes ZA, et al. Neuropharmacology. 2013 Mar;66:202-14. doi: 10.1016/j.neuropharm.2012.04.007. Epub 2012 Apr 21. Neuropharmacology. 2013. PMID: 22551786
Effects of a Balanced Translocation between Chromosomes 1 and 11 Disrupting the DISC1 Locus on White Matter Integrity.
Whalley HC, Dimitrova R, Sprooten E, Dauvermann MR, Romaniuk L, Duff B, Watson AR, Moorhead B, Bastin M, Semple SI, Giles S, Hall J, Thomson P, Roberts N, Hughes ZA, Brandon NJ, Dunlop J, Whitcher B, Blackwood DH, McIntosh AM, Lawrie SM. Whalley HC, et al. Among authors: hughes za. PLoS One. 2015 Jun 23;10(6):e0130900. doi: 10.1371/journal.pone.0130900. eCollection 2015. PLoS One. 2015. PMID: 26102360 Free PMC article.
63 results