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Discovery of 7-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridine derivatives as potent inhibitors of rearranged during transfection (RET) and RET solvent-front mutants for overcoming selpercatinib resistance.
Wu J, Mo H, An Z, Tang Z, Deng X, Zhou H, Gong Y, Zheng C, Zhuo L, Tan S. Wu J, et al. Eur J Med Chem. 2024 Sep 19;279:116891. doi: 10.1016/j.ejmech.2024.116891. Online ahead of print. Eur J Med Chem. 2024. PMID: 39316846
However, the clinical therapeutic benefits of the second-generation RET inhibitor selpercatinib are greatly compromised by acquired resistance mediated by solvent-front mutations (e.g., RET(G810 R/S/C)). Herein, we report a class of 7-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthy …
However, the clinical therapeutic benefits of the second-generation RET inhibitor selpercatinib are greatly compromised by acquired resistan …
The Photoredox Paradox: Electron and Hole Upconversion as the Hidden Secrets of Photoredox Catalysis.
Alabugin IV, Eckhardt P, Christopher KM, Opatz T. Alabugin IV, et al. J Am Chem Soc. 2024 Sep 24. doi: 10.1021/jacs.4c10422. Online ahead of print. J Am Chem Soc. 2024. PMID: 39316772 Review.
In fact, the quantum efficiency of a puzzlingly large portion of photoredox reactions exceeds 100% (i.e., the measured quantum yields (QYs) are >1). Hence, these photoredox reactions can be more than perfect with respect to photon utilization. ...We demonstrate how the …
In fact, the quantum efficiency of a puzzlingly large portion of photoredox reactions exceeds 100% (i.e., the measured quantum yields …
Coamplified Nanozyme Cocktails for Cascade Reaction-Driven Antioxidant Treatments.
Halmagyi TG, Voros A, Saringer S, Hornok V, May NV, Samu GF, Szenti I, Szerlauth A, Konya Z, Szilagyi I. Halmagyi TG, et al. ACS Appl Mater Interfaces. 2024 Sep 24. doi: 10.1021/acsami.4c12511. Online ahead of print. ACS Appl Mater Interfaces. 2024. PMID: 39316750
Surface functionalization of the particles was performed using polymers to obtain stable colloids, i.e., resistant to aggregation, under a wide range of experimental conditions. The nanozyme cocktails possessed advanced antioxidant properties with multiple enzyme-like func …
Surface functionalization of the particles was performed using polymers to obtain stable colloids, i.e., resistant to aggregation, un …
Are Coastal Marine Larvae Dispersed Less Than Would Be Expected by Ocean Currents?
Pringle JM. Pringle JM. Biol Bull. 2023 Dec;245(3):129-138. doi: 10.1086/732015. Epub 2024 Aug 26. Biol Bull. 2023. PMID: 39316744
Dispersal distance has usually been estimated indirectly by combining an observed quantity (e.g., the rate of spread of an invasive organism or genetic similarity between locations) with a model that links that quantity to the dispersal of larvae. ...
Dispersal distance has usually been estimated indirectly by combining an observed quantity (e.g., the rate of spread of an invasive o …
Women's education and attitudes toward malaria in children: Evidence from Nigeria.
Tuki D. Tuki D. Glob Public Health. 2024 Jan;19(1):2407481. doi: 10.1080/17441692.2024.2407481. Epub 2024 Sep 24. Glob Public Health. 2024. PMID: 39316726
The regression results revealed that women with primary education did not differ statistically from the reference category (i.e. women with no education) in terms of their likelihood of perceiving malaria as a deadly disease in children. ...
The regression results revealed that women with primary education did not differ statistically from the reference category (i.e. wome …
1.3 A Crystal Structure of E. coli Peptidyl-Prolyl Isomerase B with Uniform Substitution of Valine by (2S,3S)-4-Fluorovaline Reveals Structure Conservation and Multiple Staggered Rotamers of CH(2)F Groups.
Frkic RL, Tan YJ, Maleckis A, Chilton NF, Otting G, Jackson CJ. Frkic RL, et al. Biochemistry. 2024 Sep 24. doi: 10.1021/acs.biochem.4c00345. Online ahead of print. Biochemistry. 2024. PMID: 39316701
(2S,3S)-4-Fluorovaline (FVal) is an analogue of valine, where a single CH(3) group is substituted by a CH(2)F group. In the absence of valine, E. coli valyl-tRNA synthetase uses FVal as a substitute, enabling the production of proteins uniformly labeled with FVal. Here, we …
(2S,3S)-4-Fluorovaline (FVal) is an analogue of valine, where a single CH(3) group is substituted by a CH(2)F group. In the absence of valin …
LMTK2 switches on canonical TGF-β1 signaling in human bronchial epithelia.
Cruz DF, Donovan J, Hejenkowska ED, Mu F, Banerjee I, Köhn M, Farinha CM, Swiatecka-Urban A. Cruz DF, et al. Am J Physiol Lung Cell Mol Physiol. 2024 Sep 24. doi: 10.1152/ajplung.00034.2024. Online ahead of print. Am J Physiol Lung Cell Mol Physiol. 2024. PMID: 39316683
Maternal third hand exposure to e-cigarette vapor alters lung and bone marrow immune cell responses in offspring in the absence or presence of flu infection.
Donovan C, Thorpe AE, Yarak R, Coward-Smith M, Pillar AL, Gomez HM, Feng M, Bai X, Wang M, Xenaki D, Horvat JC, Chen H, Oliver BGG, Kim RY. Donovan C, et al. Am J Physiol Lung Cell Mol Physiol. 2024 Sep 24. doi: 10.1152/ajplung.00078.2024. Online ahead of print. Am J Physiol Lung Cell Mol Physiol. 2024. PMID: 39316673
There is increasing evidence that third hand exposure to e-cigarette vapor (e-vapor) can have detrimental effects on the lungs. However, whether maternal exposure during pregnancy results in harmful changes to the offspring is unknown. Using two different e-c …
There is increasing evidence that third hand exposure to e-cigarette vapor (e-vapor) can have detrimental effects on the lungs …
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