Costantino G - Search Results

1

Discovery of Multitarget Antivirals Acting on Both the Dengue Virus NS5-NS3 Interaction and the Host Src/Fyn Kinases.

Vincetti P, Caporuscio F, Kaptein S, Gioiello A, Mancino V, Suzuki Y, Yamamoto N, Crespan E, Lossani A, Maga G, Rastelli G, Castagnolo D, Neyts J, Leyssen P, Costantino G, Radi M. Vincetti P, et al. Among authors: costantino g. J Med Chem. 2015 Jun 25;58(12):4964-75. doi: 10.1021/acs.jmedchem.5b00108. Epub 2015 Jun 15. J Med Chem. 2015. PMID: 26039671

2

Modeling of poly(ADP-ribose)polymerase (PARP) inhibitors. Docking of ligands and quantitative structure-activity relationship analysis.

Costantino G, Macchiarulo A, Camaioni E, Pellicciari R. Costantino G, et al. J Med Chem. 2001 Nov 8;44(23):3786-94. doi: 10.1021/jm010116l. J Med Chem. 2001. PMID: 11689065

3

Bile acid derivatives as ligands of the farnesoid X receptor. Synthesis, evaluation, and structure-activity relationship of a series of body and side chain modified analogues of chenodeoxycholic acid.

Pellicciari R, Costantino G, Camaioni E, Sadeghpour BM, Entrena A, Willson TM, Fiorucci S, Clerici C, Gioiello A. Pellicciari R, et al. Among authors: costantino g. J Med Chem. 2004 Aug 26;47(18):4559-69. doi: 10.1021/jm049904b. J Med Chem. 2004. PMID: 15317466

4

Molecular dynamics simulation of the ligand binding domain of farnesoid X receptor. Insights into helix-12 stability and coactivator peptide stabilization in response to agonist binding.

Costantino G, Entrena-Guadix A, Macchiarulo A, Gioiello A, Pellicciari R. Costantino G, et al. J Med Chem. 2005 May 5;48(9):3251-9. doi: 10.1021/jm049182o. J Med Chem. 2005. PMID: 15857131

5

Back door modulation of the farnesoid X receptor: design, synthesis, and biological evaluation of a series of side chain modified chenodeoxycholic acid derivatives.

Pellicciari R, Gioiello A, Costantino G, Sadeghpour BM, Rizzo G, Meyer U, Parks DJ, Entrena-Guadix A, Fiorucci S. Pellicciari R, et al. Among authors: costantino g. J Med Chem. 2006 Jul 13;49(14):4208-15. doi: 10.1021/jm060294k. J Med Chem. 2006. PMID: 16821780

6

Nongenomic actions of bile acids. Synthesis and preliminary characterization of 23- and 6,23-alkyl-substituted bile acid derivatives as selective modulators for the G-protein coupled receptor TGR5.

Pellicciari R, Sato H, Gioiello A, Costantino G, Macchiarulo A, Sadeghpour BM, Giorgi G, Schoonjans K, Auwerx J. Pellicciari R, et al. Among authors: costantino g. J Med Chem. 2007 Sep 6;50(18):4265-8. doi: 10.1021/jm070633p. Epub 2007 Aug 9. J Med Chem. 2007. PMID: 17685603

7

Extending SAR of bile acids as FXR ligands: discovery of 23-N-(carbocinnamyloxy)-3α,7α-dihydroxy-6α-ethyl-24-nor-5β-cholan-23-amine.

Gioiello A, Macchiarulo A, Carotti A, Filipponi P, Costantino G, Rizzo G, Adorini L, Pellicciari R. Gioiello A, et al. Among authors: costantino g. Bioorg Med Chem. 2011 Apr 15;19(8):2650-8. doi: 10.1016/j.bmc.2011.03.004. Epub 2011 Mar 10. Bioorg Med Chem. 2011. PMID: 21459580

8

Irreversible inhibition of epidermal growth factor receptor activity by 3-aminopropanamides.

Carmi C, Galvani E, Vacondio F, Rivara S, Lodola A, Russo S, Aiello S, Bordi F, Costantino G, Cavazzoni A, Alfieri RR, Ardizzoni A, Petronini PG, Mor M. Carmi C, et al. Among authors: costantino g. J Med Chem. 2012 Mar 8;55(5):2251-64. doi: 10.1021/jm201507x. Epub 2012 Feb 17. J Med Chem. 2012. PMID: 22280453 Free article.

9

2-Aminonicotinic acid 1-oxides are chemically stable inhibitors of quinolinic acid synthesis in the mammalian brain: a step toward new antiexcitotoxic agents.

Vallerini GP, Amori L, Beato C, Tararina M, Wang XD, Schwarcz R, Costantino G. Vallerini GP, et al. Among authors: costantino g. J Med Chem. 2013 Dec 12;56(23):9482-95. doi: 10.1021/jm401249c. Epub 2013 Dec 3. J Med Chem. 2013. PMID: 24274468

10

Synthesis of atypical bile acids for use as investigative tools for the genetic defect of 3β-hydroxy-Δ(5)-C27-steroid oxidoreductase deficiency.

Gioiello A, Cerra B, Zhang W, Vallerini GP, Costantino G, De Franco F, Passeri D, Pellicciari R, Setchell KD. Gioiello A, et al. Among authors: costantino g. J Steroid Biochem Mol Biol. 2014 Oct;144 Pt B:348-60. doi: 10.1016/j.jsbmb.2014.06.008. Epub 2014 Jun 19. J Steroid Biochem Mol Biol. 2014. PMID: 24954360

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