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Ubiquitin Signaling: Chemistry Comes to the Rescue.
Mali SM, Singh SK, Eid E, Brik A. Mali SM, et al. J Am Chem Soc. 2017 Apr 12;139(14):4971-4986. doi: 10.1021/jacs.7b00089. Epub 2017 Mar 28. J Am Chem Soc. 2017. PMID: 28328208
De novo macrocyclic peptides that specifically modulate Lys48-linked ubiquitin chains.
Nawatha M, Rogers JM, Bonn SM, Livneh I, Lemma B, Mali SM, Vamisetti GB, Sun H, Bercovich B, Huang Y, Ciechanover A, Fushman D, Suga H, Brik A. Nawatha M, et al. Among authors: mali sm. Nat Chem. 2019 Jul;11(7):644-652. doi: 10.1038/s41557-019-0278-x. Epub 2019 Jun 10. Nat Chem. 2019. PMID: 31182821 Free PMC article.
The 20S as a stand-alone proteasome in cells can degrade the ubiquitin tag.
Sahu I, Mali SM, Sulkshane P, Xu C, Rozenberg A, Morag R, Sahoo MP, Singh SK, Ding Z, Wang Y, Day S, Cong Y, Kleifeld O, Brik A, Glickman MH. Sahu I, et al. Among authors: mali sm. Nat Commun. 2021 Oct 26;12(1):6173. doi: 10.1038/s41467-021-26427-0. Nat Commun. 2021. PMID: 34702852 Free PMC article.
30 results