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Proteolytic activation of pro-macrophage-stimulating protein by hepsin.
Ganesan R, Kolumam GA, Lin SJ, Xie MH, Santell L, Wu TD, Lazarus RA, Chaudhuri A, Kirchhofer D. Ganesan R, et al. Among authors: kirchhofer d. Mol Cancer Res. 2011 Sep;9(9):1175-86. doi: 10.1158/1541-7786.MCR-11-0004. Epub 2011 Aug 29. Mol Cancer Res. 2011. PMID: 21875933
Structural and functional analysis of HtrA1 and its subdomains.
Eigenbrot C, Ultsch M, Lipari MT, Moran P, Lin SJ, Ganesan R, Quan C, Tom J, Sandoval W, van Lookeren Campagne M, Kirchhofer D. Eigenbrot C, et al. Among authors: kirchhofer d. Structure. 2012 Jun 6;20(6):1040-50. doi: 10.1016/j.str.2012.03.021. Epub 2012 May 10. Structure. 2012. PMID: 22578544 Free article.
Furin-cleaved proprotein convertase subtilisin/kexin type 9 (PCSK9) is active and modulates low density lipoprotein receptor and serum cholesterol levels.
Lipari MT, Li W, Moran P, Kong-Beltran M, Sai T, Lai J, Lin SJ, Kolumam G, Zavala-Solorio J, Izrael-Tomasevic A, Arnott D, Wang J, Peterson AS, Kirchhofer D. Lipari MT, et al. Among authors: kirchhofer d. J Biol Chem. 2012 Dec 21;287(52):43482-91. doi: 10.1074/jbc.M112.380618. Epub 2012 Nov 7. J Biol Chem. 2012. PMID: 23135270 Free PMC article.
Development of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophy.
Tom I, Pham VC, Katschke KJ Jr, Li W, Liang WC, Gutierrez J, Ah Young A, Figueroa I, Eshghi ST, Lee CV, Kanodia J, Snipas SJ, Salvesen GS, Lai P, Honigberg L, van Lookeren Campagne M, Kirchhofer D, Baruch A, Lill JR. Tom I, et al. Among authors: kirchhofer d. Proc Natl Acad Sci U S A. 2020 May 5;117(18):9952-9963. doi: 10.1073/pnas.1917608117. Epub 2020 Apr 28. Proc Natl Acad Sci U S A. 2020. PMID: 32345717 Free PMC article.
Neutrophil serine protease 4 is required for mast cell-dependent vascular leakage.
AhYoung AP, Eckard SC, Gogineni A, Xi H, Lin SJ, Gerhardy S, Cox C, Phung QT, Hackney JA, Katakam AK, Reichelt M, Caplazi P, Manzanillo P, Zhang J, Roose-Girma M, Tam LW, Newman RJ, Murthy A, Weimer RM, Lill JR, Lee WP, Grimbaldeston M, Kirchhofer D, van Lookeren Campagne M. AhYoung AP, et al. Among authors: kirchhofer d. Commun Biol. 2020 Nov 19;3(1):687. doi: 10.1038/s42003-020-01407-0. Commun Biol. 2020. PMID: 33214666 Free PMC article.
132 results