Scheuermann TH - Search Results

1

Isoform-Selective and Stereoselective Inhibition of Hypoxia Inducible Factor-2.

Scheuermann TH, Stroud D, Sleet CE, Bayeh L, Shokri C, Wang H, Caldwell CG, Longgood J, MacMillan JB, Bruick RK, Gardner KH, Tambar UK. Scheuermann TH, et al. J Med Chem. 2015 Aug 13;58(15):5930-41. doi: 10.1021/acs.jmedchem.5b00529. Epub 2015 Jul 30. J Med Chem. 2015. PMID: 26226049

2

Hypoxia-inducible factors Per/ARNT/Sim domains: structure and function.

Scheuermann TH, Yang J, Zhang L, Gardner KH, Bruick RK. Scheuermann TH, et al. Methods Enzymol. 2007;435:3-24. doi: 10.1016/S0076-6879(07)35001-5. Methods Enzymol. 2007. PMID: 17998046

3

Artificial ligand binding within the HIF2alpha PAS-B domain of the HIF2 transcription factor.

Scheuermann TH, Tomchick DR, Machius M, Guo Y, Bruick RK, Gardner KH. Scheuermann TH, et al. Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):450-5. doi: 10.1073/pnas.0808092106. Epub 2009 Jan 7. Proc Natl Acad Sci U S A. 2009. PMID: 19129502 Free PMC article.

4

Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor.

Rogers JL, Bayeh L, Scheuermann TH, Longgood J, Key J, Naidoo J, Melito L, Shokri C, Frantz DE, Bruick RK, Gardner KH, MacMillan JB, Tambar UK. Rogers JL, et al. Among authors: scheuermann th. J Med Chem. 2013 Feb 28;56(4):1739-47. doi: 10.1021/jm301847z. Epub 2013 Feb 18. J Med Chem. 2013. PMID: 23363003 Free PMC article.

5

Allosteric inhibition of hypoxia inducible factor-2 with small molecules.

Scheuermann TH, Li Q, Ma HW, Key J, Zhang L, Chen R, Garcia JA, Naidoo J, Longgood J, Frantz DE, Tambar UK, Gardner KH, Bruick RK. Scheuermann TH, et al. Nat Chem Biol. 2013 Apr;9(4):271-6. doi: 10.1038/nchembio.1185. Epub 2013 Feb 24. Nat Chem Biol. 2013. PMID: 23434853 Free PMC article.

6

Coiled-coil coactivators play a structural role mediating interactions in hypoxia-inducible factor heterodimerization.

Guo Y, Scheuermann TH, Partch CL, Tomchick DR, Gardner KH. Guo Y, et al. Among authors: scheuermann th. J Biol Chem. 2015 Mar 20;290(12):7707-21. doi: 10.1074/jbc.M114.632786. Epub 2015 Jan 27. J Biol Chem. 2015. PMID: 25627682 Free PMC article.

7

Principles of ligand binding within a completely buried cavity in HIF2alpha PAS-B.

Key J, Scheuermann TH, Anderson PC, Daggett V, Gardner KH. Key J, et al. Among authors: scheuermann th. J Am Chem Soc. 2009 Dec 9;131(48):17647-54. doi: 10.1021/ja9073062. J Am Chem Soc. 2009. PMID: 19950993 Free PMC article.

8

On the acquisition and analysis of microscale thermophoresis data.

Scheuermann TH, Padrick SB, Gardner KH, Brautigam CA. Scheuermann TH, et al. Anal Biochem. 2016 Mar 1;496:79-93. doi: 10.1016/j.ab.2015.12.013. Epub 2015 Dec 29. Anal Biochem. 2016. PMID: 26739938 Free PMC article.

9

Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors.

Yin J, Babaoglu K, Brautigam CA, Clark L, Shao Z, Scheuermann TH, Harrell CM, Gotter AL, Roecker AJ, Winrow CJ, Renger JJ, Coleman PJ, Rosenbaum DM. Yin J, et al. Among authors: scheuermann th. Nat Struct Mol Biol. 2016 Apr;23(4):293-9. doi: 10.1038/nsmb.3183. Epub 2016 Mar 7. Nat Struct Mol Biol. 2016. PMID: 26950369

10

High-precision, automated integration of multiple isothermal titration calorimetric thermograms: new features of NITPIC.

Scheuermann TH, Brautigam CA. Scheuermann TH, et al. Methods. 2015 Apr;76:87-98. doi: 10.1016/j.ymeth.2014.11.024. Epub 2014 Dec 15. Methods. 2015. PMID: 25524420 Free PMC article.

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