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Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists.
Nagahara T, Saitoh T, Kutsumura N, Irukayama-Tomobe Y, Ogawa Y, Kuroda D, Gouda H, Kumagai H, Fujii H, Yanagisawa M, Nagase H. Nagahara T, et al. Among authors: yanagisawa m. J Med Chem. 2015 Oct 22;58(20):7931-7. doi: 10.1021/acs.jmedchem.5b00988. Epub 2015 Aug 26. J Med Chem. 2015. PMID: 26267383
Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes.
Willie JT, Chemelli RM, Sinton CM, Tokita S, Williams SC, Kisanuki YY, Marcus JN, Lee C, Elmquist JK, Kohlmeier KA, Leonard CS, Richardson JA, Hammer RE, Yanagisawa M. Willie JT, et al. Among authors: yanagisawa m. Neuron. 2003 Jun 5;38(5):715-30. doi: 10.1016/s0896-6273(03)00330-1. Neuron. 2003. PMID: 12797957 Free article.
Quantitative Measurement of GPCR Endocytosis via Pulse-Chase Covalent Labeling.
Kumagai H, Ikeda Y, Motozawa Y, Fujishiro M, Okamura T, Fujio K, Okazaki H, Nomura S, Takeda N, Harada M, Toko H, Takimoto E, Akazawa H, Morita H, Suzuki J, Yamazaki T, Yamamoto K, Komuro I, Yanagisawa M. Kumagai H, et al. Among authors: yanagisawa m. PLoS One. 2015 May 28;10(5):e0129394. doi: 10.1371/journal.pone.0129394. eCollection 2015. PLoS One. 2015. PMID: 26020647 Free PMC article.
Monitoring β-arrestin recruitment via β-lactamase enzyme fragment complementation: purification of peptide E as a low-affinity ligand for mammalian bombesin receptors.
Ikeda Y, Kumagai H, Okazaki H, Fujishiro M, Motozawa Y, Nomura S, Takeda N, Toko H, Takimoto E, Akazawa H, Morita H, Suzuki J, Yamazaki T, Komuro I, Yanagisawa M. Ikeda Y, et al. Among authors: yanagisawa m. PLoS One. 2015 Jun 1;10(6):e0127445. doi: 10.1371/journal.pone.0127445. eCollection 2015. PLoS One. 2015. PMID: 26030739 Free PMC article.
Peripherally administered orexin improves survival of mice with endotoxin shock.
Ogawa Y, Irukayama-Tomobe Y, Murakoshi N, Kiyama M, Ishikawa Y, Hosokawa N, Tominaga H, Uchida S, Kimura S, Kanuka M, Morita M, Hamada M, Takahashi S, Hayashi Y, Yanagisawa M. Ogawa Y, et al. Among authors: yanagisawa m. Elife. 2016 Dec 30;5:e21055. doi: 10.7554/eLife.21055. Elife. 2016. PMID: 28035899 Free PMC article.
1,180 results