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PRPF8-mediated dysregulation of hBrr2 helicase disrupts human spliceosome kinetics and 5´-splice-site selection causing tissue-specific defects.
Atkinson R, Georgiou M, Yang C, Szymanska K, Lahat A, Vasconcelos EJR, Ji Y, Moya Molina M, Collin J, Queen R, Dorgau B, Watson A, Kurzawa-Akanbi M, Laws R, Saxena A, Shyan Beh C, Siachisumo C, Goertler F, Karwatka M, Davey T, Inglehearn CF, McKibbin M, Lührmann R, Steel DH, Elliott DJ, Armstrong L, Urlaub H, Ali RR, Grellscheid SN, Johnson CA, Mozaffari-Jovin S, Lako M. Atkinson R, et al. Among authors: luhrmann r. Nat Commun. 2024 Apr 11;15(1):3138. doi: 10.1038/s41467-024-47253-0. Nat Commun. 2024. PMID: 38605034 Free PMC article.
Regulation of 3' splice site selection after step 1 of splicing by spliceosomal C* proteins.
Dybkov O, Preußner M, El Ayoubi L, Feng VY, Harnisch C, Merz K, Leupold P, Yudichev P, Agafonov DE, Will CL, Girard C, Dienemann C, Urlaub H, Kastner B, Heyd F, Lührmann R. Dybkov O, et al. Among authors: luhrmann r. Sci Adv. 2023 Mar 3;9(9):eadf1785. doi: 10.1126/sciadv.adf1785. Epub 2023 Mar 3. Sci Adv. 2023. PMID: 36867703 Free PMC article.
Activation of autophagy reverses progressive and deleterious protein aggregation in PRPF31 patient-induced pluripotent stem cell-derived retinal pigment epithelium cells.
Georgiou M, Yang C, Atkinson R, Pan KT, Buskin A, Molina MM, Collin J, Al-Aama J, Goertler F, Ludwig SEJ, Davey T, Lührmann R, Nagaraja-Grellscheid S, Johnson CA, Ali R, Armstrong L, Korolchuk V, Urlaub H, Mozaffari-Jovin S, Lako M. Georgiou M, et al. Among authors: luhrmann r. Clin Transl Med. 2022 Mar;12(3):e759. doi: 10.1002/ctm2.759. Clin Transl Med. 2022. PMID: 35297555 Free PMC article.
Structural insights into how Prp5 proofreads the pre-mRNA branch site.
Zhang Z, Rigo N, Dybkov O, Fourmann JB, Will CL, Kumar V, Urlaub H, Stark H, Lührmann R. Zhang Z, et al. Among authors: luhrmann r. Nature. 2021 Aug;596(7871):296-300. doi: 10.1038/s41586-021-03789-5. Epub 2021 Aug 4. Nature. 2021. PMID: 34349264 Free PMC article.
Localized inhibition of protein phosphatase 1 by NUAK1 promotes spliceosome activity and reveals a MYC-sensitive feedback control of transcription.
Cossa G, Roeschert I, Prinz F, Baluapuri A, Vidal RS, Schülein-Völk C, Chang YC, Ade CP, Mastrobuoni G, Girard C, Kumar A, Wortmann L, Walz S, Lührmann R, Kempa S, Kuster B, Wolf E, Mumberg D, Eilers M. Cossa G, et al. Among authors: luhrmann r. Mol Cell. 2021 Jun 3;81(11):2495. doi: 10.1016/j.molcel.2021.05.013. Mol Cell. 2021. PMID: 34087181 Free PMC article. No abstract available.
357 results