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Noncatalytic PTEN missense mutation predisposes to organ-selective cancer development in vivo.
Caserta E, Egriboz O, Wang H, Martin C, Koivisto C, Pecót T, Kladney RD, Shen C, Shim KS, Pham T, Karikomi MK, Mauntel MJ, Majumder S, Cuitino MC, Tang X, Srivastava A, Yu L, Wallace J, Mo X, Park M, Fernandez SA, Pilarski R, La Perle KM, Rosol TJ, Coppola V, Castrillon DH, Timmers C, Cohn DE, O'Malley DM, Backes F, Suarez AA, Goodfellow P, Chamberlin HM, Macrae ER, Shapiro CL, Ostrowski MC, Leone G. Caserta E, et al. Among authors: yu l. Genes Dev. 2015 Aug 15;29(16):1707-20. doi: 10.1101/gad.262568.115. Genes Dev. 2015. PMID: 26302789 Free PMC article.
Ets2 in tumor fibroblasts promotes angiogenesis in breast cancer.
Wallace JA, Li F, Balakrishnan S, Cantemir-Stone CZ, Pecot T, Martin C, Kladney RD, Sharma SM, Trimboli AJ, Fernandez SA, Yu L, Rosol TJ, Stromberg PC, Lesurf R, Hallett M, Park M, Leone G, Ostrowski MC. Wallace JA, et al. Among authors: yu l. PLoS One. 2013 Aug 16;8(8):e71533. doi: 10.1371/journal.pone.0071533. eCollection 2013. PLoS One. 2013. PMID: 23977064 Free PMC article.
Follicular thyroid cancers demonstrate dual activation of PKA and mTOR as modeled by thyroid-specific deletion of Prkar1a and Pten in mice.
Pringle DR, Vasko VV, Yu L, Manchanda PK, Lee AA, Zhang X, Kirschner JM, Parlow AF, Saji M, Jarjoura D, Ringel MD, La Perle KM, Kirschner LS. Pringle DR, et al. Among authors: yu l. J Clin Endocrinol Metab. 2014 May;99(5):E804-12. doi: 10.1210/jc.2013-3101. Epub 2014 Feb 10. J Clin Endocrinol Metab. 2014. PMID: 24512487 Free PMC article.
Protein kinase C Beta in the tumor microenvironment promotes mammary tumorigenesis.
Wallace JA, Pitarresi JR, Sharma N, Palettas M, Cuitiño MC, Sizemore ST, Yu L, Sanderlin A, Rosol TJ, Mehta KD, Sizemore GM, Ostrowski MC. Wallace JA, et al. Among authors: yu l. Front Oncol. 2014 Apr 23;4:87. doi: 10.3389/fonc.2014.00087. eCollection 2014. Front Oncol. 2014. PMID: 24795864 Free PMC article.
PTEN is a negative regulator of NK cell cytolytic function.
Briercheck EL, Trotta R, Chen L, Hartlage AS, Cole JP, Cole TD, Mao C, Banerjee PP, Hsu HT, Mace EM, Ciarlariello D, Mundy-Bosse BL, Garcia-Cao I, Scoville SD, Yu L, Pilarski R, Carson WE 3rd, Leone G, Pandolfi PP, Yu J, Orange JS, Caligiuri MA. Briercheck EL, et al. Among authors: yu l, yu j. J Immunol. 2015 Feb 15;194(4):1832-40. doi: 10.4049/jimmunol.1401224. Epub 2015 Jan 16. J Immunol. 2015. PMID: 25595786 Free PMC article.
Impact of Pre-Analytical Variables on Cancer Targeted Gene Sequencing Efficiency.
Araujo LH, Timmers C, Shilo K, Zhao W, Zhang J, Yu L, Natarajan TG, Miller CJ, Yilmaz AS, Liu T, Amann J, Lapa E Silva JR, Ferreira CG, Carbone DP. Araujo LH, et al. Among authors: yu l. PLoS One. 2015 Nov 25;10(11):e0143092. doi: 10.1371/journal.pone.0143092. eCollection 2015. PLoS One. 2015. PMID: 26605948 Free PMC article.
Genetic ablation of Smoothened in pancreatic fibroblasts increases acinar-ductal metaplasia.
Liu X, Pitarresi JR, Cuitiño MC, Kladney RD, Woelke SA, Sizemore GM, Nayak SG, Egriboz O, Schweickert PG, Yu L, Trela S, Schilling DJ, Halloran SK, Li M, Dutta S, Fernandez SA, Rosol TJ, Lesinski GB, Shakya R, Ludwig T, Konieczny SF, Leone G, Wu J, Ostrowski MC. Liu X, et al. Among authors: yu l. Genes Dev. 2016 Sep 1;30(17):1943-55. doi: 10.1101/gad.283499.116. Epub 2016 Sep 15. Genes Dev. 2016. PMID: 27633013 Free PMC article.
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