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Sec63 and Xbp1 regulate IRE1α activity and polycystic disease severity.
Fedeles SV, So JS, Shrikhande A, Lee SH, Gallagher AR, Barkauskas CE, Somlo S, Lee AH. Fedeles SV, et al. Among authors: lee sh, lee ah. J Clin Invest. 2015 May;125(5):1955-67. doi: 10.1172/JCI78863. Epub 2015 Apr 6. J Clin Invest. 2015. PMID: 25844898 Free PMC article.
Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice.
Jurczak MJ, Lee AH, Jornayvaz FR, Lee HY, Birkenfeld AL, Guigni BA, Kahn M, Samuel VT, Glimcher LH, Shulman GI. Jurczak MJ, et al. Among authors: lee ah, lee hy. J Biol Chem. 2012 Jan 20;287(4):2558-67. doi: 10.1074/jbc.M111.316760. Epub 2011 Nov 28. J Biol Chem. 2012. PMID: 22128176 Free PMC article.
ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis.
Cubillos-Ruiz JR, Silberman PC, Rutkowski MR, Chopra S, Perales-Puchalt A, Song M, Zhang S, Bettigole SE, Gupta D, Holcomb K, Ellenson LH, Caputo T, Lee AH, Conejo-Garcia JR, Glimcher LH. Cubillos-Ruiz JR, et al. Among authors: lee ah. Cell. 2015 Jun 18;161(7):1527-38. doi: 10.1016/j.cell.2015.05.025. Epub 2015 Jun 11. Cell. 2015. PMID: 26073941 Free PMC article.
Altered trafficking and stability of polycystins underlie polycystic kidney disease.
Cai Y, Fedeles SV, Dong K, Anyatonwu G, Onoe T, Mitobe M, Gao JD, Okuhara D, Tian X, Gallagher AR, Tang Z, Xie X, Lalioti MD, Lee AH, Ehrlich BE, Somlo S. Cai Y, et al. Among authors: lee ah. J Clin Invest. 2014 Dec;124(12):5129-44. doi: 10.1172/JCI67273. Epub 2014 Nov 3. J Clin Invest. 2014. PMID: 25365220 Free PMC article.
IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation.
Sun S, Shi G, Sha H, Ji Y, Han X, Shu X, Ma H, Inoue T, Gao B, Kim H, Bu P, Guber RD, Shen X, Lee AH, Iwawaki T, Paton AW, Paton JC, Fang D, Tsai B, Yates JR 3rd, Wu H, Kersten S, Long Q, Duhamel GE, Simpson KW, Qi L. Sun S, et al. Among authors: lee ah. Nat Cell Biol. 2015 Dec;17(12):1546-55. doi: 10.1038/ncb3266. Epub 2015 Nov 9. Nat Cell Biol. 2015. PMID: 26551274 Free PMC article.
1,222 results