Hexose-6-phosphate dehydrogenase controls cancer cell proliferation and migration through pleiotropic effects on the unfolded-protein response, calcium homeostasis, and redox balance.
Tsachaki M, Mladenovic N, Štambergová H, Birk J, Odermatt A.
Tsachaki M, et al. Among authors: odermatt a.
FASEB J. 2018 May;32(5):2690-2705. doi: 10.1096/fj.201700870RR. Epub 2018 Jan 2.
FASEB J. 2018.
PMID: 29295867
Free PMC article.
The H6PD gene is amplified in several types of malignancies, and earlier work pointed toward a potential involvement of the enzyme in cancer cell growth. In the present study, we demonstrated a pivotal role of H6PD in proliferation and migratory potential of 3 human …
The H6PD gene is amplified in several types of malignancies, and earlier work pointed toward a potential involvement of the enzyme in …