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Neuroprotection by JM-20 against oxygen-glucose deprivation in rat hippocampal slices: Involvement of the Akt/GSK-3β pathway.
Ramírez-Sánchez J, Simões Pires EN, Nuñez-Figueredo Y, Pardo-Andreu GL, Fonseca-Fonseca LA, Ruiz-Reyes A, Ochoa-Rodríguez E, Verdecia-Reyes Y, Delgado-Hernández R, Souza DO, Salbego C. Ramírez-Sánchez J, et al. Among authors: simoes pires en. Neurochem Int. 2015 Nov;90:215-23. doi: 10.1016/j.neuint.2015.09.003. Epub 2015 Sep 8. Neurochem Int. 2015. PMID: 26361722
A novel multi-target ligand (JM-20) protects mitochondrial integrity, inhibits brain excitatory amino acid release and reduces cerebral ischemia injury in vitro and in vivo.
Nuñez-Figueredo Y, Ramírez-Sánchez J, Hansel G, Simões Pires EN, Merino N, Valdes O, Delgado-Hernández R, Parra AL, Ochoa-Rodríguez E, Verdecia-Reyes Y, Salbego C, Costa SL, Souza DO, Pardo-Andreu GL. Nuñez-Figueredo Y, et al. Among authors: simoes pires en. Neuropharmacology. 2014 Oct;85:517-27. doi: 10.1016/j.neuropharm.2014.06.009. Epub 2014 Jun 19. Neuropharmacology. 2014. PMID: 24953828
Novel arylidene malonate derivative, KM-34, showed neuroprotective effects on in vitro and in vivo models of ischemia/reperfusion.
Ramírez-Sánchez J, Wong-Guerra M, Fonseca-Fonseca LA, Simões-Pires EN, García-Pupo L, Ochoa-Rodríguez E, Verdecia-Reyes Y, Delgado-Hernández R, Salbego C, Souza DO, Pardo-Andreu GL, Nuñez-Figueredo Y. Ramírez-Sánchez J, et al. Among authors: simoes pires en. Eur J Pharmacol. 2021 May 15;899:174025. doi: 10.1016/j.ejphar.2021.174025. Epub 2021 Mar 17. Eur J Pharmacol. 2021. PMID: 33722590 Free article.