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Plasma membrane Ca2+-ATPase overexpression depletes both mitochondrial and endoplasmic reticulum Ca2+ stores and triggers apoptosis in insulin-secreting BRIN-BD11 cells.
Jiang L, Allagnat F, Nguidjoe E, Kamagate A, Pachera N, Vanderwinden JM, Brini M, Carafoli E, Eizirik DL, Cardozo AK, Herchuelz A. Jiang L, et al. Among authors: herchuelz a. J Biol Chem. 2010 Oct 1;285(40):30634-43. doi: 10.1074/jbc.M110.116681. Epub 2010 Jul 26. J Biol Chem. 2010. PMID: 20660595 Free PMC article.
Heterozygous inactivation of the Na/Ca exchanger increases glucose-induced insulin release, β-cell proliferation, and mass.
Nguidjoe E, Sokolow S, Bigabwa S, Pachera N, D'Amico E, Allagnat F, Vanderwinden JM, Sener A, Manto M, Depreter M, Mast J, Joanny G, Montanya E, Rahier J, Cardozo AK, Eizirik DL, Schurmans S, Herchuelz A. Nguidjoe E, et al. Among authors: herchuelz a. Diabetes. 2011 Aug;60(8):2076-85. doi: 10.2337/db10-0924. Epub 2011 Jun 9. Diabetes. 2011. PMID: 21659499 Free PMC article.
Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells.
Cardozo AK, Ortis F, Storling J, Feng YM, Rasschaert J, Tonnesen M, Van Eylen F, Mandrup-Poulsen T, Herchuelz A, Eizirik DL. Cardozo AK, et al. Among authors: herchuelz a. Diabetes. 2005 Feb;54(2):452-61. doi: 10.2337/diabetes.54.2.452. Diabetes. 2005. PMID: 15677503
Initiation and execution of lipotoxic ER stress in pancreatic beta-cells.
Cunha DA, Hekerman P, Ladrière L, Bazarra-Castro A, Ortis F, Wakeham MC, Moore F, Rasschaert J, Cardozo AK, Bellomo E, Overbergh L, Mathieu C, Lupi R, Hai T, Herchuelz A, Marchetti P, Rutter GA, Eizirik DL, Cnop M. Cunha DA, et al. Among authors: herchuelz a. J Cell Sci. 2008 Jul 15;121(Pt 14):2308-18. doi: 10.1242/jcs.026062. Epub 2008 Jun 17. J Cell Sci. 2008. PMID: 18559892 Free PMC article.
The suppressor of cytokine signalling 2 (SOCS2) is a key repressor of insulin secretion.
Lebrun P, Cognard E, Gontard P, Bellon-Paul R, Filloux C, Berthault MF, Magnan C, Ruberte J, Luppo M, Pujol A, Pachera N, Herchuelz A, Bosch F, Van Obberghen E. Lebrun P, et al. Among authors: herchuelz a. Diabetologia. 2010 Sep;53(9):1935-46. doi: 10.1007/s00125-010-1786-9. Epub 2010 May 25. Diabetologia. 2010. PMID: 20499047 Free article.
196 results