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Heterozygous inactivation of the Na/Ca exchanger increases glucose-induced insulin release, β-cell proliferation, and mass.
Nguidjoe E, Sokolow S, Bigabwa S, Pachera N, D'Amico E, Allagnat F, Vanderwinden JM, Sener A, Manto M, Depreter M, Mast J, Joanny G, Montanya E, Rahier J, Cardozo AK, Eizirik DL, Schurmans S, Herchuelz A. Nguidjoe E, et al. Among authors: rahier j. Diabetes. 2011 Aug;60(8):2076-85. doi: 10.2337/db10-0924. Epub 2011 Jun 9. Diabetes. 2011. PMID: 21659499 Free PMC article.
SERCA3 ablation does not impair insulin secretion but suggests distinct roles of different sarcoendoplasmic reticulum Ca(2+) pumps for Ca(2+) homeostasis in pancreatic beta-cells.
Arredouani A, Guiot Y, Jonas JC, Liu LH, Nenquin M, Pertusa JA, Rahier J, Rolland JF, Shull GE, Stevens M, Wuytack F, Henquin JC, Gilon P. Arredouani A, et al. Among authors: rahier j. Diabetes. 2002 Nov;51(11):3245-53. doi: 10.2337/diabetes.51.11.3245. Diabetes. 2002. PMID: 12401716
340 results