Frearson JA - Search Results

1

Discovery of Indoline-2-carboxamide Derivatives as a New Class of Brain-Penetrant Inhibitors of Trypanosoma brucei.

Cleghorn LA, Albrecht S, Stojanovski L, Simeons FR, Norval S, Kime R, Collie IT, De Rycker M, Campbell L, Hallyburton I, Frearson JA, Wyatt PG, Read KD, Gilbert IH. Cleghorn LA, et al. Among authors: frearson ja. J Med Chem. 2015 Oct 8;58(19):7695-706. doi: 10.1021/acs.jmedchem.5b00596. Epub 2015 Sep 29. J Med Chem. 2015. PMID: 26418485 Free PMC article.

2

Target assessment for antiparasitic drug discovery.

Frearson JA, Wyatt PG, Gilbert IH, Fairlamb AH. Frearson JA, et al. Trends Parasitol. 2007 Dec;23(12):589-95. doi: 10.1016/j.pt.2007.08.019. Epub 2007 Oct 24. Trends Parasitol. 2007. PMID: 17962072 Free PMC article. Review.

3

Lessons learnt from assembling screening libraries for drug discovery for neglected diseases.

Brenk R, Schipani A, James D, Krasowski A, Gilbert IH, Frearson J, Wyatt PG. Brenk R, et al. ChemMedChem. 2008 Mar;3(3):435-44. doi: 10.1002/cmdc.200700139. ChemMedChem. 2008. PMID: 18064617 Free PMC article.

4

One scaffold, three binding modes: novel and selective pteridine reductase 1 inhibitors derived from fragment hits discovered by virtual screening.

Mpamhanga CP, Spinks D, Tulloch LB, Shanks EJ, Robinson DA, Collie IT, Fairlamb AH, Wyatt PG, Frearson JA, Hunter WN, Gilbert IH, Brenk R. Mpamhanga CP, et al. Among authors: frearson ja. J Med Chem. 2009 Jul 23;52(14):4454-65. doi: 10.1021/jm900414x. J Med Chem. 2009. PMID: 19527033 Free PMC article.

5

Synthesis and evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) analogues as inhibitors of trypanothione reductase.

Patterson S, Jones DC, Shanks EJ, Frearson JA, Gilbert IH, Wyatt PG, Fairlamb AH. Patterson S, et al. Among authors: frearson ja. ChemMedChem. 2009 Aug;4(8):1341-53. doi: 10.1002/cmdc.200900098. ChemMedChem. 2009. PMID: 19557802 Free PMC article.

6

HTS and hit finding in academia--from chemical genomics to drug discovery.

Frearson JA, Collie IT. Frearson JA, et al. Drug Discov Today. 2009 Dec;14(23-24):1150-8. doi: 10.1016/j.drudis.2009.09.004. Epub 2009 Sep 28. Drug Discov Today. 2009. PMID: 19793546 Free PMC article. Review.

7

Chemical validation of trypanothione synthetase: a potential drug target for human trypanosomiasis.

Torrie LS, Wyllie S, Spinks D, Oza SL, Thompson S, Harrison JR, Gilbert IH, Wyatt PG, Fairlamb AH, Frearson JA. Torrie LS, et al. Among authors: frearson ja. J Biol Chem. 2009 Dec 25;284(52):36137-36145. doi: 10.1074/jbc.M109.045336. Epub 2009 Oct 14. J Biol Chem. 2009. PMID: 19828449 Free PMC article.

8

Investigation of trypanothione reductase as a drug target in Trypanosoma brucei.

Spinks D, Shanks EJ, Cleghorn LA, McElroy S, Jones D, James D, Fairlamb AH, Frearson JA, Wyatt PG, Gilbert IH. Spinks D, et al. Among authors: frearson ja. ChemMedChem. 2009 Dec;4(12):2060-9. doi: 10.1002/cmdc.200900262. ChemMedChem. 2009. PMID: 19924760 Free PMC article.

9

Nuclear DBF-2-related kinases are essential regulators of cytokinesis in bloodstream stage Trypanosoma brucei.

Ma J, Benz C, Grimaldi R, Stockdale C, Wyatt P, Frearson J, Hammarton TC. Ma J, et al. J Biol Chem. 2010 May 14;285(20):15356-15368. doi: 10.1074/jbc.M109.074591. Epub 2010 Mar 15. J Biol Chem. 2010. PMID: 20231285 Free PMC article.

10

N-myristoyltransferase inhibitors as new leads to treat sleeping sickness.

Frearson JA, Brand S, McElroy SP, Cleghorn LA, Smid O, Stojanovski L, Price HP, Guther ML, Torrie LS, Robinson DA, Hallyburton I, Mpamhanga CP, Brannigan JA, Wilkinson AJ, Hodgkinson M, Hui R, Qiu W, Raimi OG, van Aalten DM, Brenk R, Gilbert IH, Read KD, Fairlamb AH, Ferguson MA, Smith DF, Wyatt PG. Frearson JA, et al. Nature. 2010 Apr 1;464(7289):728-32. doi: 10.1038/nature08893. Nature. 2010. PMID: 20360736 Free PMC article.

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