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Selective superoxide generation within mitochondria by the targeted redox cycler MitoParaquat.
Robb EL, Gawel JM, Aksentijević D, Cochemé HM, Stewart TS, Shchepinova MM, Qiang H, Prime TA, Bright TP, James AM, Shattock MJ, Senn HM, Hartley RC, Murphy MP. Robb EL, et al. Among authors: murphy mp. Free Radic Biol Med. 2015 Dec;89:883-94. doi: 10.1016/j.freeradbiomed.2015.08.021. Epub 2015 Oct 8. Free Radic Biol Med. 2015. PMID: 26454075 Free article.
How mitochondrial damage affects cell function.
James AM, Murphy MP. James AM, et al. Among authors: murphy mp. J Biomed Sci. 2002;9(6 Pt 1):475-87. doi: 10.1159/000064721. J Biomed Sci. 2002. PMID: 12372986 Review.
Specific targeting of a DNA-alkylating reagent to mitochondria. Synthesis and characterization of [4-((11aS)-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-on-8-oxy)butyl]-triphenylphosphonium iodide.
James AM, Blaikie FH, Smith RA, Lightowlers RN, Smith PM, Murphy MP. James AM, et al. Among authors: murphy mp. Eur J Biochem. 2003 Jul;270(13):2827-36. doi: 10.1046/j.1432-1033.2003.03660.x. Eur J Biochem. 2003. PMID: 12823553 Free article.
Superoxide activates uncoupling proteins by generating carbon-centered radicals and initiating lipid peroxidation: studies using a mitochondria-targeted spin trap derived from alpha-phenyl-N-tert-butylnitrone.
Murphy MP, Echtay KS, Blaikie FH, Asin-Cayuela J, Cocheme HM, Green K, Buckingham JA, Taylor ER, Hurrell F, Hughes G, Miwa S, Cooper CE, Svistunenko DA, Smith RA, Brand MD. Murphy MP, et al. J Biol Chem. 2003 Dec 5;278(49):48534-45. doi: 10.1074/jbc.M308529200. Epub 2003 Sep 12. J Biol Chem. 2003. PMID: 12972420 Free article.
Targeting coenzyme Q derivatives to mitochondria.
Smith RA, Kelso GF, James AM, Murphy MP. Smith RA, et al. Among authors: murphy mp. Methods Enzymol. 2004;382:45-67. doi: 10.1016/S0076-6879(04)82003-2. Methods Enzymol. 2004. PMID: 15047095 Review. No abstract available.
794 results