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Treatment of hypophosphatasia by muscle-directed expression of bone-targeted alkaline phosphatase via self-complementary AAV8 vector.
Nakamura-Takahashi A, Miyake K, Watanabe A, Hirai Y, Iijima O, Miyake N, Adachi K, Nitahara-Kasahara Y, Kinoshita H, Noguchi T, Abe S, Narisawa S, Millán JL, Shimada T, Okada T. Nakamura-Takahashi A, et al. Mol Ther Methods Clin Dev. 2016 Feb 3;3:15059. doi: 10.1038/mtm.2015.59. eCollection 2016. Mol Ther Methods Clin Dev. 2016. PMID: 26904710 Free PMC article.
High-Level Expression of Alkaline Phosphatase by Adeno-Associated Virus Vector Ameliorates Pathological Bone Structure in a Hypophosphatasia Mouse Model.
Nakamura-Takahashi A, Tanase T, Matsunaga S, Shintani S, Abe S, Nitahara-Kasahara Y, Watanabe A, Hirai Y, Okada T, Yamaguchi A, Kasahara M. Nakamura-Takahashi A, et al. Calcif Tissue Int. 2020 Jun;106(6):665-677. doi: 10.1007/s00223-020-00676-5. Epub 2020 Feb 19. Calcif Tissue Int. 2020. PMID: 32076747
Prenatal enzyme replacement therapy for Akp2 -/- mice with lethal hypophosphatasia.
Hasegawa A, Nakamura-Takahashi A, Kasahara M, Saso N, Narisawa S, Millán JL, Samura O, Sago H, Okamoto A, Umezawa A. Hasegawa A, et al. Among authors: nakamura takahashi a. Regen Ther. 2021 Jul 5;18:168-175. doi: 10.1016/j.reth.2021.06.002. eCollection 2021 Dec. Regen Ther. 2021. PMID: 34277899 Free PMC article.
Impact of Dental Pulp Stem Cells Overexpressing Hepatocyte Growth Factor after Cerebral Ischemia/Reperfusion in Rats.
Sowa K, Nito C, Nakajima M, Suda S, Nishiyama Y, Sakamoto Y, Nitahara-Kasahara Y, Nakamura-Takahashi A, Ueda M, Kimura K, Okada T. Sowa K, et al. Among authors: nakamura takahashi a. Mol Ther Methods Clin Dev. 2018 Aug 4;10:281-290. doi: 10.1016/j.omtm.2018.07.009. eCollection 2018 Sep 21. Mol Ther Methods Clin Dev. 2018. PMID: 30151417 Free PMC article.
A new mouse model of Ehlers-Danlos syndrome generated using CRISPR/Cas9-mediated genomic editing.
Nitahara-Kasahara Y, Mizumoto S, Inoue YU, Saka S, Posadas-Herrera G, Nakamura-Takahashi A, Takahashi Y, Hashimoto A, Konishi K, Miyata S, Masuda C, Matsumoto E, Maruoka Y, Yoshizawa T, Tanase T, Inoue T, Yamada S, Nomura Y, Takeda S, Watanabe A, Kosho T, Okada T. Nitahara-Kasahara Y, et al. Among authors: nakamura takahashi a. Dis Model Mech. 2021 Dec 1;14(12):dmm048963. doi: 10.1242/dmm.048963. Epub 2021 Dec 23. Dis Model Mech. 2021. PMID: 34850861 Free PMC article.
Myopathy Associated With Dermatan Sulfate-Deficient Decorin and Myostatin in Musculocontractural Ehlers-Danlos Syndrome: A Mouse Model Investigation.
Nitahara-Kasahara Y, Posadas-Herrera G, Mizumoto S, Nakamura-Takahashi A, Inoue YU, Inoue T, Nomura Y, Takeda S, Yamada S, Kosho T, Okada T. Nitahara-Kasahara Y, et al. Among authors: nakamura takahashi a. Front Cell Dev Biol. 2021 Oct 11;9:695021. doi: 10.3389/fcell.2021.695021. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 34708033 Free PMC article.
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