Villareal VA - Search Results

1

Targeting host lipid synthesis and metabolism to inhibit dengue and hepatitis C viruses.

Villareal VA, Rodgers MA, Costello DA, Yang PL. Villareal VA, et al. Antiviral Res. 2015 Dec;124:110-21. doi: 10.1016/j.antiviral.2015.10.013. Epub 2015 Oct 23. Antiviral Res. 2015. PMID: 26526588 Free PMC article. Review.

2

Lipid metabolite profiling identifies desmosterol metabolism as a new antiviral target for hepatitis C virus.

Rodgers MA, Villareal VA, Schaefer EA, Peng LF, Corey KE, Chung RT, Yang PL. Rodgers MA, et al. Among authors: villareal va. J Am Chem Soc. 2012 Apr 25;134(16):6896-9. doi: 10.1021/ja207391q. Epub 2012 Apr 11. J Am Chem Soc. 2012. PMID: 22480142 Free PMC article.

3

The bioactive lipid 4-hydroxyphenyl retinamide inhibits flavivirus replication.

Carocci M, Hinshaw SM, Rodgers MA, Villareal VA, Burri DJ, Pilankatta R, Maharaj NP, Gack MU, Stavale EJ, Warfield KL, Yang PL. Carocci M, et al. Among authors: villareal va. Antimicrob Agents Chemother. 2015 Jan;59(1):85-95. doi: 10.1128/AAC.04177-14. Epub 2014 Oct 13. Antimicrob Agents Chemother. 2015. PMID: 25313218 Free PMC article.

4

Hepatitis C Virus Selectively Alters the Intracellular Localization of Desmosterol.

Villareal VA, Fu D, Costello DA, Xie XS, Yang PL. Villareal VA, et al. ACS Chem Biol. 2016 Jul 15;11(7):1827-33. doi: 10.1021/acschembio.6b00324. Epub 2016 May 6. ACS Chem Biol. 2016. PMID: 27128812 Free PMC article.

5

Desmosterol Increases Lipid Bilayer Fluidity during Hepatitis C Virus Infection.

Costello DA, Villareal VA, Yang PL. Costello DA, et al. Among authors: villareal va. ACS Infect Dis. 2016 Nov 11;2(11):852-862. doi: 10.1021/acsinfecdis.6b00086. Epub 2016 Aug 25. ACS Infect Dis. 2016. PMID: 27933788 Free PMC article.

6

Hepatitis C virus NS3-4A protease regulates the lipid environment for RNA replication by cleaving host enzyme 24-dehydrocholesterol reductase.

Tallorin L, Villareal VA, Hsia CY, Rodgers MA, Burri DJ, Pfeil MP, Llopis PM, Lindenbach BD, Yang PL. Tallorin L, et al. Among authors: villareal va. J Biol Chem. 2020 Aug 28;295(35):12426-12436. doi: 10.1074/jbc.RA120.013455. Epub 2020 Jul 8. J Biol Chem. 2020. PMID: 32641492 Free PMC article.

7

Anti-HCV drugs in the pipeline.

Yang PL, Gao M, Lin K, Liu Q, Villareal VA. Yang PL, et al. Among authors: villareal va. Curr Opin Virol. 2011 Dec;1(6):607-16. doi: 10.1016/j.coviro.2011.10.019. Epub 2011 Nov 13. Curr Opin Virol. 2011. PMID: 22440918 Free PMC article. Review.

8

A heteronuclear zero quantum coherence Nz-exchange experiment that resolves resonance overlap and its application to measure the rates of heme binding to the IsdC protein.

Robson SA, Peterson R, Bouchard LS, Villareal VA, Clubb RT. Robson SA, et al. Among authors: villareal va. J Am Chem Soc. 2010 Jul 21;132(28):9522-3. doi: 10.1021/ja1017865. J Am Chem Soc. 2010. PMID: 20578738 Free PMC article.

9

Transient weak protein-protein complexes transfer heme across the cell wall of Staphylococcus aureus.

Villareal VA, Spirig T, Robson SA, Liu M, Lei B, Clubb RT. Villareal VA, et al. J Am Chem Soc. 2011 Sep 14;133(36):14176-9. doi: 10.1021/ja203805b. Epub 2011 Aug 19. J Am Chem Soc. 2011. PMID: 21834592 Free PMC article.

10

The IsdC protein from Staphylococcus aureus uses a flexible binding pocket to capture heme.

Villareal VA, Pilpa RM, Robson SA, Fadeev EA, Clubb RT. Villareal VA, et al. J Biol Chem. 2008 Nov 14;283(46):31591-600. doi: 10.1074/jbc.M801126200. Epub 2008 Aug 20. J Biol Chem. 2008. PMID: 18715872 Free PMC article.

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