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Novel orally active inhibitors of β-1,3-glucan synthesis derived from enfumafungin.
Bioorg Med Chem Lett. 2015 Dec 15;25(24):5813-8. doi: 10.1016/j.bmcl.2015.10.011. Epub 2015 Oct 9.
Bioorg Med Chem Lett. 2015.
PMID: 26542966
Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor.
Apgar JM, Wilkening RR, Parker DL Jr, Meng D, Wildonger KJ, Sperbeck D, Greenlee ML, Balkovec JM, Flattery AM, Abruzzo GK, Galgoci AM, Giacobbe RA, Gill CJ, Hsu MJ, Liberator P, Misura AS, Motyl M, Nielsen Kahn J, Powles M, Racine F, Dragovic J, Fan W, Kirwan R, Lee S, Liu H, Mamai A, Nelson K, Peel M.
Apgar JM, et al. Among authors: nielsen kahn j.
Bioorg Med Chem Lett. 2021 Jan 15;32:127661. doi: 10.1016/j.bmcl.2020.127661. Epub 2020 Nov 4.
Bioorg Med Chem Lett. 2021.
PMID: 33160023
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The discovery of moriniafungin, a novel sordarin derivative produced by Morinia pestalozzioides.
Basilio A, Justice M, Harris G, Bills G, Collado J, de la Cruz M, Diez MT, Hernandez P, Liberator P, Nielsen kahn J, Pelaez F, Platas G, Schmatz D, Shastry M, Tormo JR, Andersen GR, Vicente F.
Basilio A, et al. Among authors: nielsen kahn j.
Bioorg Med Chem. 2006 Jan 15;14(2):560-6. doi: 10.1016/j.bmc.2005.08.046. Epub 2005 Sep 23.
Bioorg Med Chem. 2006.
PMID: 16183294
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Sordarin derivatives induce a novel conformation of the yeast ribosome translocation factor eEF2.
Søe R, Mosley RT, Justice M, Nielsen-Kahn J, Shastry M, Merrill AR, Andersen GR.
Søe R, et al. Among authors: nielsen kahn j.
J Biol Chem. 2007 Jan 5;282(1):657-66. doi: 10.1074/jbc.M607830200. Epub 2006 Nov 2.
J Biol Chem. 2007.
PMID: 17082187
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