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The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition.
Sperber H, Mathieu J, Wang Y, Ferreccio A, Hesson J, Xu Z, Fischer KA, Devi A, Detraux D, Gu H, Battle SL, Showalter M, Valensisi C, Bielas JH, Ericson NG, Margaretha L, Robitaille AM, Margineantu D, Fiehn O, Hockenbery D, Blau CA, Raftery D, Margolin AA, Hawkins RD, Moon RT, Ware CB, Ruohola-Baker H. Sperber H, et al. Among authors: hockenbery d. Nat Cell Biol. 2015 Dec;17(12):1523-35. doi: 10.1038/ncb3264. Epub 2015 Nov 16. Nat Cell Biol. 2015. PMID: 26571212 Free PMC article.
Mitochondrial functions in stem cells.
Margineantu DH, Hockenbery DM. Margineantu DH, et al. Curr Opin Genet Dev. 2016 Jun;38:110-117. doi: 10.1016/j.gde.2016.05.004. Epub 2016 Jun 5. Curr Opin Genet Dev. 2016. PMID: 27269732 Review.
Pan-cancer transcriptional signatures predictive of oncogenic mutations reveal that Fbw7 regulates cancer cell oxidative metabolism.
Davis RJ, Gönen M, Margineantu DH, Handeli S, Swanger J, Hoellerbauer P, Paddison PJ, Gu H, Raftery D, Grim JE, Hockenbery DM, Margolin AA, Clurman BE. Davis RJ, et al. Among authors: hockenbery dm. Proc Natl Acad Sci U S A. 2018 May 22;115(21):5462-5467. doi: 10.1073/pnas.1718338115. Epub 2018 May 7. Proc Natl Acad Sci U S A. 2018. PMID: 29735700 Free PMC article.
Hsp90 inhibition decreases mitochondrial protein turnover.
Margineantu DH, Emerson CB, Diaz D, Hockenbery DM. Margineantu DH, et al. Among authors: hockenbery dm. PLoS One. 2007 Oct 24;2(10):e1066. doi: 10.1371/journal.pone.0001066. PLoS One. 2007. PMID: 17957250 Free PMC article.
Bcl-2 family proteins as regulators of oxidative stress.
Susnow N, Zeng L, Margineantu D, Hockenbery DM. Susnow N, et al. Among authors: hockenbery dm. Semin Cancer Biol. 2009 Feb;19(1):42-9. doi: 10.1016/j.semcancer.2008.12.002. Epub 2008 Dec 24. Semin Cancer Biol. 2009. PMID: 19138742 Free PMC article. Review.
Evasion of apoptosis is one of the hallmarks of cancer [Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100:57-70], relevant to tumorigenesis as well as resistance to cytotoxic drugs, and deregulation of Bcl-2 proteins is observed in many cancers [Manion MK, …
Evasion of apoptosis is one of the hallmarks of cancer [Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100:57-70], releva …
Fnip1 regulates skeletal muscle fiber type specification, fatigue resistance, and susceptibility to muscular dystrophy.
Reyes NL, Banks GB, Tsang M, Margineantu D, Gu H, Djukovic D, Chan J, Torres M, Liggitt HD, Hirenallur-S DK, Hockenbery DM, Raftery D, Iritani BM. Reyes NL, et al. Among authors: hockenbery dm. Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):424-9. doi: 10.1073/pnas.1413021112. Epub 2014 Dec 29. Proc Natl Acad Sci U S A. 2015. PMID: 25548157 Free PMC article.
Loss of Fnip1 alters kidney developmental transcriptional program and synergizes with TSC1 loss to promote mTORC1 activation and renal cyst formation.
Centini R, Tsang M, Iwata T, Park H, Delrow J, Margineantu D, Iritani BM, Gu H, Liggitt HD, Kang J, Kang L, Hockenbery DM, Raftery D, Iritani BM. Centini R, et al. Among authors: hockenbery dm. PLoS One. 2018 Jun 13;13(6):e0197973. doi: 10.1371/journal.pone.0197973. eCollection 2018. PLoS One. 2018. PMID: 29897930 Free PMC article.
124 results