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α-synuclein interacts with SOD1 and promotes its oligomerization.
Helferich AM, Ruf WP, Grozdanov V, Freischmidt A, Feiler MS, Zondler L, Ludolph AC, McLean PJ, Weishaupt JH, Danzer KM. Helferich AM, et al. Among authors: danzer km. Mol Neurodegener. 2015 Dec 8;10:66. doi: 10.1186/s13024-015-0062-3. Mol Neurodegener. 2015. PMID: 26643113 Free PMC article.
Drug targets from genetics: α-synuclein.
Danzer KM, McLean PJ. Danzer KM, et al. CNS Neurol Disord Drug Targets. 2011 Sep 1;10(6):712-23. doi: 10.2174/187152711797247867. CNS Neurol Disord Drug Targets. 2011. PMID: 21838671 Free PMC article. Review.
Autoproteolytic fragments are intermediates in the oligomerization/aggregation of the Parkinson's disease protein alpha-synuclein as revealed by ion mobility mass spectrometry.
Vlad C, Lindner K, Karreman C, Schildknecht S, Leist M, Tomczyk N, Rontree J, Langridge J, Danzer K, Ciossek T, Petre A, Gross ML, Hengerer B, Przybylski M. Vlad C, et al. Chembiochem. 2011 Dec 16;12(18):2740-4. doi: 10.1002/cbic.201100569. Epub 2011 Nov 7. Chembiochem. 2011. PMID: 22162214 Free PMC article.
Exosomal cell-to-cell transmission of alpha synuclein oligomers.
Danzer KM, Kranich LR, Ruf WP, Cagsal-Getkin O, Winslow AR, Zhu L, Vanderburg CR, McLean PJ. Danzer KM, et al. Mol Neurodegener. 2012 Aug 24;7:42. doi: 10.1186/1750-1326-7-42. Mol Neurodegener. 2012. PMID: 22920859 Free PMC article.
Chronic treatment with novel small molecule Hsp90 inhibitors rescues striatal dopamine levels but not α-synuclein-induced neuronal cell loss.
McFarland NR, Dimant H, Kibuuka L, Ebrahimi-Fakhari D, Desjardins CA, Danzer KM, Danzer M, Fan Z, Schwarzschild MA, Hirst W, McLean PJ. McFarland NR, et al. Among authors: danzer km, danzer m. PLoS One. 2014 Jan 20;9(1):e86048. doi: 10.1371/journal.pone.0086048. eCollection 2014. PLoS One. 2014. PMID: 24465863 Free PMC article.
74 results