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The inhibition of IGF-1 signaling promotes proteostasis by enhancing protein aggregation and deposition.
Moll L, Ben-Gedalya T, Reuveni H, Cohen E. Moll L, et al. FASEB J. 2016 Apr;30(4):1656-69. doi: 10.1096/fj.15-281675. Epub 2015 Dec 31. FASEB J. 2016. PMID: 26722006
Our findings show that IGF-1 signaling inhibitors in general and NT219 in particular can promote proteostasis in mammalian cells by hyperaggregating hazardous proteins, thereby bearing the potential to postpone the onset and slow the progression of neurodegenerative illnesses in …
Our findings show that IGF-1 signaling inhibitors in general and NT219 in particular can promote proteostasis in mammalian cells by hyperagg …
Insulin receptor signaling mediates APP processing and β-amyloid accumulation without altering survival in a transgenic mouse model of Alzheimer's disease.
Stöhr O, Schilbach K, Moll L, Hettich MM, Freude S, Wunderlich FT, Ernst M, Zemva J, Brüning JC, Krone W, Udelhoven M, Schubert M. Stöhr O, et al. Among authors: moll l. Age (Dordr). 2013 Feb;35(1):83-101. doi: 10.1007/s11357-011-9333-2. Epub 2011 Nov 6. Age (Dordr). 2013. PMID: 22057897 Free PMC article.
74 results