Frydenvang K - Search Results

1

Synthesis and Pharmacology of Mono-, Di-, and Trialkyl-Substituted 7-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides Combined with X-ray Structure Analysis to Understand the Unexpected Structure-Activity Relationship at AMPA Receptors.

Larsen AP, Francotte P, Frydenvang K, Tapken D, Goffin E, Fraikin P, Caignard DH, Lestage P, Danober L, Pirotte B, Kastrup JS. Larsen AP, et al. Among authors: frydenvang k. ACS Chem Neurosci. 2016 Mar 16;7(3):378-90. doi: 10.1021/acschemneuro.5b00318. Epub 2016 Feb 1. ACS Chem Neurosci. 2016. PMID: 26771108

2

Synthesis and pharmacology of 3-isoxazolol amino acids as selective antagonists at group I metabotropic glutamic acid receptors.

Madsen U, Bräuner-Osborne H, Frydenvang K, Hvene L, Johansen TN, Nielsen B, Sánchez C, Stensbøl TB, Bischoff F, Krogsgaard-Larsen P. Madsen U, et al. Among authors: frydenvang k. J Med Chem. 2001 Mar 29;44(7):1051-9. doi: 10.1021/jm000441t. J Med Chem. 2001. PMID: 11297452

3

Stereostructure-activity studies on agonists at the AMPA and kainate subtypes of ionotropic glutamate receptors.

Johansen TN, Greenwood JR, Frydenvang K, Madsen U, Krogsgaard-Larsen P. Johansen TN, et al. Among authors: frydenvang k. Chirality. 2003 Feb;15(2):167-79. doi: 10.1002/chir.10177. Chirality. 2003. PMID: 12520509 Review.

4

Carbamoylcholine homologs: synthesis and pharmacology at nicotinic acetylcholine receptors.

Jensen AA, Mikkelsen I, Frølund B, Frydenvang K, Brehm L, Jaroszewski JW, Bräuner-Osborne H, Falch E, Krogsgaard-Larsen P. Jensen AA, et al. Among authors: frydenvang k. Eur J Pharmacol. 2004 Aug 23;497(2):125-37. doi: 10.1016/j.ejphar.2004.06.038. Eur J Pharmacol. 2004. PMID: 15306197

5

A tetrazolyl-substituted subtype-selective AMPA receptor agonist.

Vogensen SB, Frydenvang K, Greenwood JR, Postorino G, Nielsen B, Pickering DS, Ebert B, Bølcho U, Egebjerg J, Gajhede M, Kastrup JS, Johansen TN, Clausen RP, Krogsgaard-Larsen P. Vogensen SB, et al. Among authors: frydenvang k. J Med Chem. 2007 May 17;50(10):2408-14. doi: 10.1021/jm061439q. Epub 2007 Apr 25. J Med Chem. 2007. PMID: 17455929

6

Molecular mechanism of agonist recognition by the ligand-binding core of the ionotropic glutamate receptor 4.

Kasper C, Frydenvang K, Naur P, Gajhede M, Pickering DS, Kastrup JS. Kasper C, et al. Among authors: frydenvang k. FEBS Lett. 2008 Dec 10;582(29):4089-94. doi: 10.1016/j.febslet.2008.11.005. Epub 2008 Nov 18. FEBS Lett. 2008. PMID: 19022251 Free article.

7

Full domain closure of the ligand-binding core of the ionotropic glutamate receptor iGluR5 induced by the high affinity agonist dysiherbaine and the functional antagonist 8,9-dideoxyneodysiherbaine.

Frydenvang K, Lash LL, Naur P, Postila PA, Pickering DS, Smith CM, Gajhede M, Sasaki M, Sakai R, Pentikaïnen OT, Swanson GT, Kastrup JS. Frydenvang K, et al. J Biol Chem. 2009 May 22;284(21):14219-29. doi: 10.1074/jbc.M808547200. Epub 2009 Mar 18. J Biol Chem. 2009. PMID: 19297335 Free PMC article.

8

Lessons from more than 80 structures of the GluA2 ligand-binding domain in complex with agonists, antagonists and allosteric modulators.

Pøhlsgaard J, Frydenvang K, Madsen U, Kastrup JS. Pøhlsgaard J, et al. Among authors: frydenvang k. Neuropharmacology. 2011 Jan;60(1):135-50. doi: 10.1016/j.neuropharm.2010.08.004. Epub 2010 Aug 14. Neuropharmacology. 2011. PMID: 20713069 Review.

9

Structure-activity relationship study of first selective inhibitor of excitatory amino acid transporter subtype 1: 2-Amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101).

Erichsen MN, Huynh TH, Abrahamsen B, Bastlund JF, Bundgaard C, Monrad O, Bekker-Jensen A, Nielsen CW, Frydenvang K, Jensen AA, Bunch L. Erichsen MN, et al. Among authors: frydenvang k. J Med Chem. 2010 Oct 14;53(19):7180-91. doi: 10.1021/jm1009154. J Med Chem. 2010. PMID: 20857912

10

Biostructural and pharmacological studies of bicyclic analogues of the 3-isoxazolol glutamate receptor agonist ibotenic acid.

Frydenvang K, Pickering DS, Greenwood JR, Krogsgaard-Larsen N, Brehm L, Nielsen B, Vogensen SB, Hald H, Kastrup JS, Krogsgaard-Larsen P, Clausen RP. Frydenvang K, et al. J Med Chem. 2010 Dec 9;53(23):8354-61. doi: 10.1021/jm101218a. Epub 2010 Nov 10. J Med Chem. 2010. PMID: 21067182

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