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Mitochondrial thiol modification by a targeted electrophile inhibits metabolism in breast adenocarcinoma cells by inhibiting enzyme activity and protein levels.
Smith MR, Vayalil PK, Zhou F, Benavides GA, Beggs RR, Golzarian H, Nijampatnam B, Oliver PG, Smith RA, Murphy MP, Velu SE, Landar A. Smith MR, et al. Among authors: landar a. Redox Biol. 2016 Aug;8:136-48. doi: 10.1016/j.redox.2016.01.002. Epub 2016 Jan 8. Redox Biol. 2016. PMID: 26774751 Free PMC article.
A novel class of mitochondria-targeted soft electrophiles modifies mitochondrial proteins and inhibits mitochondrial metabolism in breast cancer cells through redox mechanisms.
Vayalil PK, Oh JY, Zhou F, Diers AR, Smith MR, Golzarian H, Oliver PG, Smith RA, Murphy MP, Velu SE, Landar A. Vayalil PK, et al. Among authors: landar a. PLoS One. 2015 Mar 18;10(3):e0120460. doi: 10.1371/journal.pone.0120460. eCollection 2015. PLoS One. 2015. PMID: 25785718 Free PMC article.
Detection of electrophile-sensitive proteins.
Wall SB, Smith MR, Ricart K, Zhou F, Vayalil PK, Oh JY, Landar A. Wall SB, et al. Among authors: landar a. Biochim Biophys Acta. 2014 Feb;1840(2):913-22. doi: 10.1016/j.bbagen.2013.09.003. Epub 2013 Sep 8. Biochim Biophys Acta. 2014. PMID: 24021887 Free PMC article. Review.
Assessing bioenergetic function in response to oxidative stress by metabolic profiling.
Dranka BP, Benavides GA, Diers AR, Giordano S, Zelickson BR, Reily C, Zou L, Chatham JC, Hill BG, Zhang J, Landar A, Darley-Usmar VM. Dranka BP, et al. Among authors: landar a. Free Radic Biol Med. 2011 Nov 1;51(9):1621-35. doi: 10.1016/j.freeradbiomed.2011.08.005. Epub 2011 Aug 16. Free Radic Biol Med. 2011. PMID: 21872656 Free PMC article.
Mitochondria-targeted heme oxygenase-1 decreases oxidative stress in renal epithelial cells.
Bolisetty S, Traylor A, Zarjou A, Johnson MS, Benavides GA, Ricart K, Boddu R, Moore RD, Landar A, Barnes S, Darley-Usmar V, Agarwal A. Bolisetty S, et al. Among authors: landar a. Am J Physiol Renal Physiol. 2013 Aug 1;305(3):F255-64. doi: 10.1152/ajprenal.00160.2013. Epub 2013 May 29. Am J Physiol Renal Physiol. 2013. PMID: 23720344 Free PMC article.
63 results