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[Eco-pharma of approved drug focused on mitochondria fission].
Shimauchi T, Nishimura A, Ishikawa T, Nishida M. Shimauchi T, et al. Nihon Yakurigaku Zasshi. 2017;149(6):269-273. doi: 10.1254/fpj.149.269. Nihon Yakurigaku Zasshi. 2017. PMID: 28626119 Japanese. No abstract available.
TRPC3-Nox2 complex mediates doxorubicin-induced myocardial atrophy.
Shimauchi T, Numaga-Tomita T, Ito T, Nishimura A, Matsukane R, Oda S, Hoka S, Ide T, Koitabashi N, Uchida K, Sumimoto H, Mori Y, Nishida M. Shimauchi T, et al. JCI Insight. 2017 Aug 3;2(15):e93358. doi: 10.1172/jci.insight.93358. eCollection 2017 Aug 3. JCI Insight. 2017. PMID: 28768915 Free PMC article.
TRPC3 Channels in Cardiac Fibrosis.
Numaga-Tomita T, Oda S, Shimauchi T, Nishimura A, Mangmool S, Nishida M. Numaga-Tomita T, et al. Among authors: shimauchi t. Front Cardiovasc Med. 2017 Sep 7;4:56. doi: 10.3389/fcvm.2017.00056. eCollection 2017. Front Cardiovasc Med. 2017. PMID: 28936433 Free PMC article. Review.
Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence.
Nishimura A, Shimauchi T, Tanaka T, Shimoda K, Toyama T, Kitajima N, Ishikawa T, Shindo N, Numaga-Tomita T, Yasuda S, Sato Y, Kuwahara K, Kumagai Y, Akaike T, Ide T, Ojida A, Mori Y, Nishida M. Nishimura A, et al. Among authors: shimauchi t. Sci Signal. 2018 Nov 13;11(556):eaat5185. doi: 10.1126/scisignal.aat5185. Sci Signal. 2018. PMID: 30425165
TRPC6 regulates phenotypic switching of vascular smooth muscle cells through plasma membrane potential-dependent coupling with PTEN.
Numaga-Tomita T, Shimauchi T, Oda S, Tanaka T, Nishiyama K, Nishimura A, Birnbaumer L, Mori Y, Nishida M. Numaga-Tomita T, et al. Among authors: shimauchi t. FASEB J. 2019 Sep;33(9):9785-9796. doi: 10.1096/fj.201802811R. Epub 2019 Jun 4. FASEB J. 2019. PMID: 31162976 Free PMC article.
Given the marked up-regulation of TRPC6 observed in vascular disorders, our findings suggest that attenuation of TRPC6 channel activity in pathologic VSMCs could be a rational strategy to maintain vascular quality control by fine-tuning of VSMC phenotypic switching.-Numaga-Tomita …
Given the marked up-regulation of TRPC6 observed in vascular disorders, our findings suggest that attenuation of TRPC6 channel activity in p …
A TRPC3/6 Channel Inhibitor Promotes Arteriogenesis after Hind-Limb Ischemia.
Shimauchi T, Numaga-Tomita T, Kato Y, Morimoto H, Sakata K, Matsukane R, Nishimura A, Nishiyama K, Shibuta A, Horiuchi Y, Kurose H, Kim SG, Urano Y, Ohshima T, Nishida M. Shimauchi T, et al. Cells. 2022 Jun 27;11(13):2041. doi: 10.3390/cells11132041. Cells. 2022. PMID: 35805125 Free PMC article.
Inhibition of transient receptor potential cation channel 6 promotes capillary arterialization during post-ischaemic blood flow recovery.
Numaga-Tomita T, Shimauchi T, Kato Y, Nishiyama K, Nishimura A, Sakata K, Inada H, Kita S, Iwamoto T, Nabekura J, Birnbaumer L, Mori Y, Nishida M. Numaga-Tomita T, et al. Among authors: shimauchi t. Br J Pharmacol. 2023 Jan;180(1):94-110. doi: 10.1111/bph.15942. Epub 2022 Oct 3. Br J Pharmacol. 2023. PMID: 36068079 Free PMC article.
141 results